Recent studies have shown participation of long non‐coding RNAs (lncRNAs) in the pathogenesis of psoriasis. Several mechanisms might be involved in the dysregulation of expression of lncRNAs in patients with psoriasis, among them is the presence of single nucleotide polymorphisms (SNPs) which modulate expression or function of these transcripts. In the present work, we genotyped three SNPs (rs12826786, rs1899663 and rs4759314) of the HOX Transcript Antisense RNA (HOTAIR) in 286 patients with psoriasis and 300 control subjects. The rs12826786 was associated with risk of psoriasis in dominant model (TC + TT vs. CC: OR (95% CI) = 1.59 (0.1.14–2.22), adjusted p‐value = .02). In the allelic model, T allele of this SNP significantly increased the risk of psoriasis compared with the C allele (OR (95% CI) = 1.35 (1.06–1.71), adjusted p‐value = .04). Other SNPs were not associated with risk of psoriasis in any inheritance model. No significant difference was found in haplotype frequencies between cases and controls. The current work shows association between a genomic variant within HOTAIR and risk of psoriasis. The clinical significance of this finding should be assessed in future studies.

中文翻译：

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HOX 转录反义 RNA (HOTAIR) 中的单核苷酸多态性与银屑病风险相关

最近的研究表明，长链非编码 RNA (lncRNA) 参与了银屑病的发病机制。银屑病患者 lncRNA 表达失调可能涉及多种机制，其中包括调节这些转录物表达或功能的单核苷酸多态性 (SNP) 的存在。在目前的工作中，我们对 286 名银屑病患者和 300 名对照受试者的 HOX 转录反义 RNA (HOTAIR) 的三个 SNP（rs12826786、rs1899663 和 rs4759314）进行了基因分型。rs12826786 与显性模型中的银屑病风险相关（TC + TT 与 CC：OR (95% CI) = 1.59 (0.1.14–2.22)，调整后的 p 值 = .02）。在等位基因模型中，与 C 等位基因相比，该 SNP 的 T 等位基因显着增加了银屑病风险（OR (95% CI) = 1.35 (1.06–1.71)，调整后的 p 值 = .04）。在任何遗传模型中，其他 SNP 均与银屑病风险无关。病例和对照之间的单倍型频率没有发现显着差异。当前的工作显示了 HOTAIR 中的基因组变异与银屑病风险之间的关联。这一发现的临床意义应在未来的研究中进行评估。