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Modulation of human endogenous retroviruses -H, -W and -K transcription by microbes.
Microbes and Infection ( IF 5.8 ) Pub Date : 2020-02-06 , DOI: 10.1016/j.micinf.2020.01.006
Massimiliano Bergallo 1 , Ilaria Galliano 1 , Paola Montanari 1 , Elena Zaniol 1 , Elisa Graziano 1 , Cristina Calvi 1 , Carla Alliaudi 1 , Valentina Daprà 1 , Francesco Savino 2
Affiliation  

The human endogenous retroviruses (HERVs) are endogenous retroviruses that are inserted into the germ cell DNA of humans over 30 million years ago. Using real-time RT-PCR we describe HERV modulation by commensal microbes in the human gut.

Infants, exclusively or predominant breast milk feeding, less than 12 weeks of age, during bacteria gut colonization, were assessed for eligibility.

Our data demonstrate that the colonization with commensal microbes, in particular, Bifidobacterium spp., of the gut causes modulation of HERVs.



中文翻译:

微生物对人内源性逆转录病毒-H,-W和-K转录的调节。

人类内源性逆转录病毒(HERV)是一种内源性逆转录病毒,已在三千万年前插入人类生殖细胞DNA中。使用实时RT-PCR,我们描述了人类肠道中共生微生物对HERV的调节作用。

对细菌肠道定植期间小于或等于12周龄的婴儿(全部或主要母乳喂养)进行了评估。

我们的数据表明,肠道内共生微生物(特别是双歧杆菌属)的定殖会引起HERV的调节。

更新日期:2020-02-06
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