Objective To evaluate the difference between hepatitis B virus related hepatocellular carcinoma (HBV-HCC) and non-HBV non-HCV hepatocellular carcinoma (NBNC-HCC) patients based on clinical features and prognosis. Methods A total of 175 patients with HCC were enrolled. Patients’ characteristics were extracted from medical records. Among them, 107 patients were positive for HBsAg and negative for HCV-Ab while 68 patients were negative for HBsAg and HCV-Ab. Results The patients in the NBNC-HCC group were significantly older than those in the HBV-HCC group ( P = 0.045). Moreover, vascular invasion was found in 23.4% of HBV-HCC patients, which was significantly higher than that in the NBNC-HCC patients with 10.3% ( P = 0.029). Kaplan-Meier analysis revealed that HBV-HCC patients had significantly worse outcomes in terms of overall survival ( P = 0.036). Compared with the NBNC-HCC patients, the HBV-HCC patients had a significantly worse disease-free survival ( P = 0.0018). The multivariate analysis results indicated that TNM stage (HR = 1.541, 95%CI 1.072–2.412, P = 0.002) and HBV infection (HR = 1.087, 95%CI 1.012–1.655, P = 0.042) were independent risk variables for overall survival. While vascular invasion (HR = 1.562, 95%CI 1.013–2.815, P = 0.042) and HBV infection (HR = 1.650, 95%CI 1.017–2.676, P = 0.037) were independent risk factors associated with disease-free survival. Conclusion Our data revealed that HBV-HCC is more common in young males with vascular invasion, while NBNC-HCC occurs mostly in elderly patients, and overall survival rate is significantly better than that of HBV-HCC. Our study therefore provides evidence that patients with HBV-HCC require closer follow-up due to their poor prognosis.

中文翻译：

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HBV相关和非B非C肝细胞癌的临床特征和结局比较

目的根据临床特征和预后评估乙型肝炎病毒相关性肝细胞癌（HBV-HCC）与非HBV非HCV肝细胞癌（NBNC-HCC）患者的差异。方法共纳入175例HCC患者。从医疗记录中提取患者的特征。其中 107 例 HBsAg 阳性和 HCV-Ab 阴性，68 例 HBsAg 和 HCV-Ab 阴性。结果 NBNC-HCC组患者年龄明显大于HBV-HCC组（P=0.045）。此外，23.4%的HBV-HCC患者出现血管侵犯，明显高于NBNC-HCC患者的10.3%（P=0.029）。Kaplan-Meier 分析显示，HBV-HCC 患者的总生存期明显更差（P = 0.036）。与 NBNC-HCC 患者相比，HBV-HCC 患者的无病生存期明显更差（ P = 0.0018）。多变量分析结果表明，TNM分期（HR = 1.541, 95%CI 1.072-2.412, P = 0.002）和HBV感染（HR = 1.087, 95%CI 1.012-1.655, P = 0.042）是总生存期的独立风险变量. 而血管侵犯（HR = 1.562, 95%CI 1.013–2.815, P = 0.042）和 HBV 感染（HR = 1.650, 95%CI 1.017–2.676, P = 0.037）是与无病生存相关的独立危险因素。结论 我们的数据显示 HBV-HCC 多见于有血管侵犯的年轻男性，而 NBNC-HCC 多见于老年患者，总体生存率明显优于 HBV-HCC。