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Reversing Hemianopia by Multisensory Training Under Anesthesia
Frontiers in Systems Neuroscience ( IF 3 ) Pub Date : 2020-01-31 , DOI: 10.3389/fnsys.2020.00004
Huai Jiang 1 , Benjamin A Rowland 1 , Barry E Stein 1
Affiliation  

Hemianopia is characterized by blindness in one half of the visual field and is a common consequence of stroke and unilateral injury to the visual cortex. There are few effective rehabilitative strategies that can relieve it. Using the cat as an animal model of hemianopia, we found that blindness induced by lesions targeting all contiguous areas of the visual cortex could be rapidly reversed by a non-invasive, multisensory (auditory-visual) exposure procedure even while animals were anesthetized. Surprisingly few trials were required to reinstate vision in the previously blind hemisphere. That rehabilitation was possible under anesthesia indicates that the visuomotor behaviors commonly believed to be essential are not required for this recovery, nor are factors such as attention, motivation, reward, or the various other cognitive features that are generally thought to facilitate neuro-rehabilitative therapies.

中文翻译:

麻醉下多感官训练逆转偏盲

偏盲的特点是一半视野失明,是中风和单侧视觉皮层损伤的常见后果。很少有有效的康复策略可以缓解它。使用猫作为偏盲的动物模型,我们发现即使在动物被麻醉的情况下,通过非侵入性、多感官(听觉-视觉)暴露程序也可以迅速逆转由针对视觉皮层所有连续区域的病变引起的失明。令人惊讶的是,在以前失明的半球中恢复视力所需的试验很少。在麻醉下康复是可能的,这表明这种恢复不需要通常认为必不可少的视觉运动行为,注意力、动机、奖励等因素也不是必需的。
更新日期:2020-01-31
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