OBJECTIVE To investigate the measurement reproducibility of the maximum diameter on MRI routine sequence (T1WI, T2WI, DWI) and CT in peripheral and central lung cancer, and to provide reference standard for evaluating treatment responses for lung cancer. METHODS 53 patients with lung cancer underwent CT and 3.0T MR scanning. The maximum diameter was measured according to the RECIST1.1 standard on images of CT (lung and enhanced mediastinal window), MRI T2-BLADE, axial T1-VIBE and DWIb0, DWIb300, DWIb800, respectively. The reproducibility of the diameters was analyzed with intraclass correlation coefficient (ICC), and the distribution of measurement points with the Bland-Altman method. The difference analysis was assessed by paired samples t-test and nonparametric rank sum test, P < 0.05 is considered statistically significant. RESULTS Reproducibility of diameters derived from routine MRI and CT was good (ICC > 0.75). For peripheral lung cancer, there was no significant difference in diameters between CT and MRI. While for central lung cancer, there was significant difference in diameters measured between using CT and each MRI sequence. However, the diameters derived from T1-VIBE and T2-BLADE were not significantly different from all DWI sequences. CONCLUSIONS For peripheral lung cancer, the measurement on CT and routine MRI sequences can potentially replace each other after comprehensive consideration of examination purposes, but for central lung cancer, alternative use of CT and MRI in evaluating treatment responses for lung cancer should needs extra attention. The diameter measurement of lung cancer on DWI is consistent with that on T1WI and T2WI, suggesting that DWI can provide functional and morphological information.

中文翻译：

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测量肺癌CT和MR成像之间最大直径可重复性的初步分析。

目的探讨外周和中部肺癌MRI常规序列（T1WI，T2WI，DWI）和CT的最大直径测量重现性，为评估肺癌的治疗反应提供参考标准。方法对53例肺癌患者进行CT和3.0T MR扫描。根据RECIST1.1标准，分别在CT（肺部和增强的纵隔窗），MRI T2-BLADE，轴向T1-VIBE和DWIb0，DWIb300，DWIb800的图像上测量最大直径。使用类内相关系数（ICC）分析直径的可重复性，并使用Bland-Altman方法分析测量点的分布。通过配对样本t检验和非参数秩和检验评估差异分析，P <0.05被认为具有统计学意义。结果常规MRI和CT获得的直径可重复性良好（ICC> 0.75）。对于周围型肺癌，CT和MRI之间的直径没有显着差异。对于中心型肺癌，使用CT和每个MRI序列测得的直径存在显着差异。但是，从T1-VIBE和T2-BLADE衍生的直径与所有DWI序列均无显着差异。结论对于周围型肺癌，在综合考虑检查目的后，CT和常规MRI序列的测量有可能相互替代，但对于中心型肺癌，CT和MRI在评估肺癌治疗反应中的替代用途应格外注意。DWI上肺癌的直径测量与T1WI和T2WI上的一致，