We conducted a systematic review and network meta-analysis to determine the comparative efficacy of antibiotics used to control bovine respiratory disease (BRD) in beef cattle on feedlots. The information sources for the review were: MEDLINE®, MEDLINE In-Process and MEDLINE® Daily, AGRICOLA, Epub Ahead of Print, Cambridge Agricultural and Biological Index, Science Citation Index, Conference Proceedings Citation Index – Science, the Proceedings of the American Association of Bovine Practitioners, World Buiatrics Conference, and the United States Food and Drug Administration Freedom of Information New Animal Drug Applications summaries. The eligible population was weaned beef cattle raised in intensive systems. The interventions of interest were injectable antibiotics used at the time the cattle arrived at the feedlot. The outcome of interest was the diagnosis of BRD within 45 days of arrival at the feedlot. The network meta-analysis included data from 46 studies and 167 study arms identified in the review. The results suggest that macrolides are the most effective antibiotics for the reduction of BRD incidence. Injectable oxytetracycline effectively controlled BRD compared with no antibiotics; however, it was less effective than macrolide treatment. Because oxytetracycline is already commonly used to prevent, control, and treat BRD in groups of feedlot cattle, the use of injectable oxytetracycline for BRD control might have advantages from an antibiotic stewardship perspective.

中文翻译：

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在到达饲养场后的前 45 天内，对用于控制牛呼吸道疾病的注射抗生素选择进行系统回顾和网络荟萃分析

我们进行了系统评价和网络荟萃分析，以确定用于控制饲养场肉牛牛呼吸道疾病 (BRD) 的抗生素的比较功效。审查的信息来源是：MEDLINE®、MEDLINE In-Process 和 MEDLINE® Daily、AGRICOLA、Epub Ahead of Print、Cambridge Agriculture and Biological Index、Science Citation Index、Conference Proceedings Citation Index – Science、Proceedings of the American Association牛从业者、世界 Buiatrics 会议和美国食品和药物管理局信息自由新动物药物应用摘要。符合条件的人群是在集约化系统中饲养的断奶肉牛。感兴趣的干预措施是牛到达饲养场时使用的可注射抗生素。感兴趣的结果是在到达饲养场的 45 天内诊断出 BRD。网络荟萃分析包括来自审查中确定的 46 项研究和 167 个研究组的数据。结果表明，大环内酯类是降低BRD发病率最有效的抗生素。与不使用抗生素相比，注射用土霉素可有效控制BRD；然而，它不如大环内酯治疗有效。由于土霉素已普遍用于预防、控制和治疗饲养场牛群的 BRD，因此从抗生素管理的角度来看，使用注射用土霉素控制 BRD 可能具有优势。结果表明，大环内酯类是降低BRD发病率最有效的抗生素。与不使用抗生素相比，注射用土霉素可有效控制BRD；然而，它不如大环内酯治疗有效。由于土霉素已普遍用于预防、控制和治疗饲养场牛群的 BRD，因此从抗生素管理的角度来看，使用注射用土霉素控制 BRD 可能具有优势。结果表明，大环内酯类是降低BRD发病率最有效的抗生素。与不使用抗生素相比，注射用土霉素可有效控制BRD；然而，它不如大环内酯治疗有效。由于土霉素已普遍用于预防、控制和治疗饲养场牛群的 BRD，因此从抗生素管理的角度来看，使用注射用土霉素控制 BRD 可能具有优势。