Background: Biosensors are widely applied for the detection of bio-molecules in blood glucose , cholesterol, and gene. Cellulose as the most dominating natural polymer has attracted more and more interest, especially in the field of medicine such as advanced medical diagnosis. Cellulose could endow biosensors with improved biocompatibility, biodegradability and nontoxicity, which could help in medical diagnosis. This mini-review summarizes the current development of cellulose-based biosensors as well as their applications in medical diagnosis in recent years.

Methods: After reviewing recent years’ publications we can say that, there are several kinds of cellulose used in biosensors including different cellulose derivatives, bacterial cellulose and nanocellulose. Different types of cellulose-based biosensors, such as membrane, nano-cellulose and others were briefly described in addition to the detection principle. Cellulose-based biosensors were summarized as in the previous papers. The description of various methods used for preparing cellulose-based biosensors was also provided.

Results: Cellulose and its derivatives with their unique chemical structure proved to be versatile materials providing a good platform for achieving immobilizing bioactive molecules in biosensors. These cellulose-based biosensors possess various desirable properties such as accuracy, sensitivity, convenience, low cost and fast response. Among them, cellulose paper-based biosensors have the advantages of low cost and easy operation. Nano-cellulose has unique properties such as a large aspect ratio, good dispersing ability and high absorption capacity.

Conclusion: Cellulose displays a promising application in biosensors which could be used to detect different bio-molecules such as glucose, lactate, urea, gene, cell, amino acid, cholesterol, protein and hydroquinone. In future, the attention will be focused on designing miniaturized, multifunctional, intelligent and integrated biosensors. Creation of low cost and environmentally friendly biosensors is also very important.

背景：生物传感器被广泛应用于检测血糖，胆固醇和基因中的生物分子。纤维素作为最主要的天然聚合物已引起越来越多的关注，特别是在医学领域，例如高级医学诊断。纤维素可以赋予生物传感器更高的生物相容性，生物降解性和无毒性，这有助于医学诊断。这篇小型综述总结了近年来纤维素基生物传感器的发展及其在医学诊断中的应用。

方法：回顾近年来的出版物后，我们可以说，生物传感器中使用的纤维素有多种，包括不同的纤维素衍生物，细菌纤维素和纳米纤维素。除了检测原理外，还简要介绍了不同类型的基于纤维素的生物传感器，例如膜，纳米纤维素等。与以前的论文一样，对基于纤维素的生物传感器进行了总结。还提供了用于制备基于纤维素的生物传感器的各种方法的描述。

结果：纤维素及其衍生物具有独特的化学结构，被证明是通用材料，为将生物活性分子固定在生物传感器中提供了良好的平台。这些基于纤维素的生物传感器具有各种期望的特性，例如准确性，灵敏度，便利性，低成本和快速响应。其中，基于纤维素纸的生物传感器具有低成本和易于操作的优点。纳米纤维素具有独特的性质，例如长径比大，良好的分散能力和高吸收能力。

结论：纤维素在生物传感器中具有广阔的应用前景，可用于检测不同的生物分子，例如葡萄糖，乳酸，尿素，基因，细胞，氨基酸，胆固醇，蛋白质和对苯二酚。将来，注意力将集中在设计小型，多功能，智能和集成的生物传感器上。创建低成本和环保的生物传感器也非常重要。