In adult animals, it is well established that stress has a proactive effect on psychostimulant responses. However, whether only a short period of stress during adolescence can also affect cocaine responses later in life and what mechanisms are involved are unknown. Here, we showed that 5 days of social isolation during rat adolescence had a long-term impact on anxiety-like behaviors, cocaine-induced conditioned place preference, and the expression of sensitization during adulthood. At the molecular level, social isolation decreased the activity of the Wnt/β-catenin pathway in the prefrontal cortex (PFC). Furthermore, after the expression of cocaine sensitization, isolated rats showed an increase in this pathway in the nucleus accumbens. Together, these findings suggest that, adolescent social isolation by altering the Wnt/β-catenin pathway in the developing PFC might increase the cocaine responses during adulthood, introducing this pathway as a novel neuroadaptation in the cortical-accumbens connection that may mediate a stress-induced increase in vulnerability to drugs.

中文翻译：

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青春期雄性大鼠的社会隔离抑制前额叶皮层的Wnt /β-Catenin通路，并增强成年期的焦虑和可卡因诱导的可塑性。

在成年动物中，众所周知，压力对精神刺激反应具有积极作用。但是，青春期短时的压力是否还会影响可卡因的生命后期反应，涉及的机制尚不清楚。在这里，我们显示了大鼠青春期的5天社交隔离对焦虑样行为，可卡因诱导的条件性位置偏爱以及成年期间的敏化表达具有长期影响。在分子水平上，社会隔离降低了前额叶皮层（PFC）中Wnt /β-catenin途径的活性。此外，在表达可卡因致敏后，离体大鼠在伏隔核中显示出该途径的增加。这些发现共同表明，