ABSTRACT Inflammation is associated with increased risk for chronic degenerative diseases, as well as age-related functional declines across many systems and tissues. Current understandings of inflammation, aging, and human health are based on studies conducted almost exclusively in high-income nations that rely primarily on baseline measures of chronic inflammation. This analysis investigates the inflammatory response to vaccination as a predictor of cardiovascular disease (CVD) among older women in the Philippines, a lower-middle income nation with rising rates of overweight/obesity and relatively high burdens of infectious disease. Concentrations of C-reactive protein (CRP) were measured at baseline and 72 h following influenza vaccination in 530 women (mean age = 55.2 years). Ankle-brachial index (ABI) – an indicator of peripheral arterial disease and broader CVD risk – was measured approximately three years later. The magnitude of CRP response to vaccination was positively associated with ABI, indicating that a larger inflammatory response predicts lower CVD risk. Baseline CRP was negatively associated with CRP response to vaccination, and was not associated with ABI independently of CRP response. These results suggest that research across ecological settings, and with more dynamic measures of inflammatory response and regulation, may yield important insights into the associations among inflammation, aging, and disease.

中文翻译：

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流感疫苗的C反应蛋白反应可预测菲律宾的心血管疾病风险。

摘要炎症与慢性退行性疾病的风险增加以及许多系统和组织的年龄相关功能下降有关。当前对炎症，衰老和人类健康的理解是基于几乎完全在高收入国家进行的研究，这些国家主要依赖于慢性炎症的基线指标。这项分析调查了菲律宾（一个中等偏下收入国家，超重/肥胖率不断上升，传染病负担相对较高）中老年妇女对疫苗的炎症反应，将其作为心血管疾病（CVD）的预测指标。在基线和流感疫苗接种后72小时，对530名妇女（平均年龄= 55.2岁）测量了C反应蛋白（CRP）的浓度。大约三年后，对踝臂指数（ABI）进行了测量，该指数是周围动脉疾病和更广泛的CVD风险的指标。CRP对疫苗反应的强度与ABI正相关，表明更大的炎症反应预示着较低的CVD风险。基线CRP与疫苗接种的CRP反应呈负相关，并且与CBI反应无关地与ABI没有关系。这些结果表明，在整个生态环境中进行的研究以及对炎症反应和调节的更动态测量，可能会对炎症，衰老和疾病之间的联系产生重要的见解。表明较大的炎症反应预示着较低的CVD风险。基线CRP与疫苗接种的CRP反应呈负相关，并且与CBI反应无关地与ABI没有关系。这些结果表明，在整个生态环境中进行的研究以及对炎症反应和调节的更动态测量，可能会对炎症，衰老和疾病之间的联系产生重要的见解。表明较大的炎症反应预示着较低的CVD风险。基线CRP与疫苗接种的CRP反应呈负相关，并且与CBI反应无关地与ABI没有关系。这些结果表明，在整个生态环境中进行的研究以及对炎症反应和调节的更动态测量，可能会对炎症，衰老和疾病之间的联系产生重要的见解。