Abstract Delineation of the intricacies of protein function from macromolecular structure constitutes a continual obstacle in the study of cell and pathogen biology. Structure-based phylogenetic analysis has emerged as a powerful tool for addressing this challenge, allowing the detection and quantification of conserved architectural properties between proteins, including those with low or no detectable sequence homology. With a focus on viral protein structure, we highlight how a number of investigations have utilized this powerful method to infer common functionality and ancestry.

中文翻译：

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通过基于结构的系统发育分类揭示病毒关系

摘要 从大分子结构描述蛋白质功能的复杂性构成了细胞和病原体生物学研究的持续障碍。基于结构的系统发育分析已成为解决这一挑战的有力工具，允许检测和量化蛋白质之间的保守结构特性，包括那些具有低或不可检测序列同源性的蛋白质。以病毒蛋白结构为重点，我们强调了许多研究如何利用这种强大的方法来推断共同的功能和祖先。