BACKGROUND In dogs with protein-losing enteropathy (PLE), data on the clinical characteristics of food-responsive PLE (FR-PLE) remain scarce. OBJECTIVE To determine the clinical characteristics of FR-PLE in dogs responsive to ultralow-fat diet (ULFD) management. ANIMALS Thirty-three dogs diagnosed with PLE based on standard diagnostic criteria. METHODS Retrospective review of medical records. Clinical findings were compared between dogs with FR-PLE (FR-PLE group) and those with immunosuppressant-responsive PLE (IR-PLE) or nonresponsive PLE (NR-PLE) (IR/NR-PLE group). The area under the curve (AUC) of a receiver operating characteristic curve was used to evaluate the ability of factors to differentiate the FR-PLE and IR/NR-PLE groups. Survival time was compared between the FR-PLE and IR/NR-PLE groups. RESULTS Twenty-three dogs responded to ULFD management and were diagnosed with FR-PLE. The canine chronic enteropathy clinical activity index (CCECAI) was significantly lower in the FR-PLE group than in the IR/NR-PLE group (P < .001). The AUC of CCECAI for differentiating the FR-PLE group was 0.935 (95% confidence interval [CI], 0.845-1.000) with an optimal cutoff value of 8 (sensitivity, 0.826; specificity, 0.889). Survival times were significantly longer in the FR-PLE group (median, not reached) than in the IR/NR-PLE group (median, 432 days; P < .001). CONCLUSIONS AND CLINICAL IMPORTANCE Dogs that respond to ULFD management and are diagnosed with FR-PLE are expected to have a favorable prognosis. Clinical scores, specifically the CCECAI, could be useful for differentiating FR-PLE from IR-PLE or NR-PLE.

中文翻译：

---

具有食物反应性蛋白丢失性肠病的犬的临床特征。

背景技术在患有蛋白丢失性肠病（PLE）的狗中，关于食物反应性PLE（FR-PLE）的临床特征的数据仍然很少。目的确定对超低脂饮食（ULFD）处理有反应的犬中FR-PLE的临床特征。动物根据标准诊断标准诊断为PLE的33只狗。方法回顾性病历。比较了具有FR-PLE的狗（FR-PLE组）和具有免疫抑制剂反应性PLE（IR-PLE）或无反应性PLE（NR-PLE）的狗（IR / NR-PLE组）的临床发现。接收器工作特性曲线的曲线下面积（AUC）用于评估因素区分FR-PLE和IR / NR-PLE组的能力。比较了FR-PLE组和IR / NR-PLE组的生存时间。结果23只狗对ULFD的治疗有反应，并被诊断出患有FR-PLE。FR-PLE组的犬慢性肠病临床活动指数（CCECAI）显着低于IR / NR-PLE组（P <.001）。CCECAI用于区分FR-PLE组的AUC为0.935（95％置信区间[CI]，0.845-1.000），最佳临界值为8（敏感性，0.826；特异性，0.889）。FR-PLE组的生存时间（中位数，未达到）显着长于IR / NR-PLE组（中位数，432天； P <.001）。结论和临床意义对ULFD治疗有反应并被诊断为FR-PLE的狗预后良好。临床评分，特别是CCECAI，可能有助于区分FR-PLE和IR-PLE或NR-PLE。