BACKGROUND This study investigated the remineralisation effect of bioactive glass on artificial dentine caries. METHODS Dentine disks with artificial caries were treated with bioactive glass (group BAG), casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) (group CPP-ACP), sodium fluoride glycerol (group F) or deionized water (group W). All disks were subjected to pH cycling for 28 days subsequently. The topography, microhardness and remineralisation depth of the dentine carious lesion were assessed by atomic force microscopy (AFM), microhardness testing and confocal laser scanning microscope (CLSM), respectively. RESULTS AFM images indicated mineral depositions on the surface of the carious lesion in group BAG. The changes of Vickers hardness number (ΔVHN, mean ± SD) after pH cycling were 9.67 ± 3.60, 6.06 ± 3.83, 5.00 ± 2.19 and - 1.90 ± 2.09 (p < 0.001) in group BAG, group CPP-ACP, group F and group W, respectively. The remineralisation depth (mean ± SD) of the carious lesion in group BAG, group CPP-ACP, group F and group W were 165 ± 11 μm, 111 ± 11 μm, 75 ± 6 μm and 0 μm (p < 0.001), respectively. CONCLUSION Bioactive glass possessed a promising remineralisation effect on artificial dentine caries and could be a therapeutic choice for caries management.

中文翻译：

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45S5生物活性玻璃对牙本质中人工龋齿的再矿化作用。

背景技术本研究研究了生物活性玻璃对人造牙本质龋齿的再矿化作用。方法用生物活性玻璃（BAG组），酪蛋白磷酸肽无定形磷酸钙（CPP-ACP）（CPP-ACP组），氟化钠甘油（F组）或去离子水（W组）处理带有龋齿的牙盘。随后将所有圆盘进行pH循环28天。通过原子力显微镜（AFM），显微硬度测试和共聚焦激光扫描显微镜（CLSM）分别评估了牙本质龋病的形貌，显微硬度和再矿化深度。结果AFM图像表明BAG组龋病灶表面有矿物质沉积。pH循环后的维氏硬度值（ΔVHN，平均值±SD）的变化为9.67±3.60、6.06±3.83、5.00±2.19和-1。BAG组，CPP-ACP组，F组和W组分别为90±2.09（p <0.001）。BAG组，CPP-ACP组，F组和W组的龋病的再矿化深度（平均值±SD）为165±11μm，111±11μm，75±6μm和0μm（p <0.001），分别。结论生物活性玻璃对人工牙本质龋具有理想的再矿化作用，可作为龋齿治疗的治疗选择。