Characterization of endogenous Claudin1 expression, motility and susceptibility to Hepatitis C Virus in CRISPR knock‐in cells,Biology of the Cell

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Characterization of endogenous Claudin1 expression, motility and susceptibility to Hepatitis C Virus in CRISPR knock‐in cells
Biology of the Cell ( IF 2.7 ) Pub Date : 2020-02-20 , DOI: 10.1111/boc.201900085
Camille M H Clément _{1,

2,

3,

4} , Maika S Deffieu _{1,

2} , Cristina M Dorobantu _{3,

4} , Thomas F Baumert _{3,

4,

5} , Nilda Vanesa Ayala-Nunez _{1,

2,

3,

4} , Yves Mély _{4,

6} , Philippe Ronde _{4,

6} , Raphael Gaudin _{1,

2,

3,

4}

Affiliation

Claudin‐1 (CLDN1) is a four‐span transmembrane protein localised at cell–cell tight junctions (TJs), playing an important role in epithelial impermeability and tissue homoeostasis under physiological conditions. Moreover, CLDN1 expression is up‐regulated in several cancers, and the level of CLDN1 expression has been proposed as a prognostic marker of patient survival.

中文翻译：

CRISPR 敲入细胞中内源性 Claudin1 表达、运动性和对丙型肝炎病毒易感性的表征

Claudin-1 (CLDN1) 是一种位于细胞-细胞紧密连接 (TJs) 的四跨跨膜蛋白，在生理条件下在上皮不透性和组织稳态中起重要作用。此外，CLDN1 表达在几种癌症中上调，CLDN1 表达水平已被提议作为患者生存的预后标志物。

更新日期：2020-02-20

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