Novel wound dressings composed of chitosan (Ch) and hyaluronan (HA) loaded with tiopronin or captopril as antiinflammatory drugs were prepared. Composite biomembranes were examined in skin wounds of ischemic rabbits with the aim to accelerate the process of healing. The results proved that the biomembranes composed of Ch/HA/tiopronin or Ch/HA/captopril facilitated healing of skin wounds compared to untreated animals and animals treated with Ch/HA membranes. These results were confirmed by histology. Cu(II) ions and ascorbate-induced high-molar-mass HA degradation by means of rotational viscometry was performed and the ability of the both drugs to scavenge reactive oxygen species was evaluated. The results showed that captopril as well as tiopronin decreased the rate of HA degradation exclusively at higher concentrations.

中文翻译：

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用硫普罗宁或卡托普利负载的复合生物膜修复皮肤伤口。

制备了由壳聚糖（Ch）和透明质酸（HA）组成的新型伤口敷料，其中负载了噻普罗宁或卡托普利作为抗炎药。在缺血兔的皮肤伤口中检查了复合生物膜，旨在加速其愈合过程。结果证明，与未经处理的动物和经Ch / HA膜处理的动物相比，由Ch / HA /硫蛋白或Ch / HA /卡托普利组成的生物膜促进皮肤伤口的愈合。这些结果通过组织学证实。进行了Cu（II）离子和抗坏血酸诱导的高分子量HA的旋转粘度测定，并评估了这两种药物清除活性氧的能力。结果表明，卡托普利和硫普罗宁仅在较高浓度下降低了HA的降解速率。