Equine veterinarians frequently inject aminoglycoside antibiotics intra‐articularly, either to treat septic arthritis or for prophylaxis with other medications when injecting joints for osteoarthritis. Although aminoglycosides have been demonstrated to be toxic to equine mesenchymal stem cells (MSC), their effects on resident joint cells have not been previously investigated. Moreover, safe and effective intra‐articular doses have not been defined.

中文翻译：

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Amikacin 在体外诱导马软骨细胞和滑膜细胞中的快速剂量依赖性凋亡细胞死亡。

马兽医经常在关节内注射氨基糖苷类抗生素，以治疗化脓性关节炎或在注射关节治疗骨关节炎时使用其他药物进行预防。尽管氨基糖苷类已被证明对马间充质干细胞 (MSC) 有毒，但之前尚未研究过它们对常驻关节细胞的影响。此外，尚未确定安全有效的关节内剂量。