当前位置: X-MOL 学术Rejuvenation Res. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Jeanne Calment's Unique 122-Year Life Span: Facts and Factors; Longevity History in Her Genealogical Tree.
Rejuvenation Research ( IF 2.6 ) Pub Date : 2020-01-13 , DOI: 10.1089/rej.2019.2298
François Robin-Champigneul 1
Affiliation  

Jeanne Calment's (JC) still unmatched validated human life span of 122 years and 164 days, over 3 years longer than any other, surprises many. While her case is broadly accepted as a golden standard of validation, her record age still raises skepticism among some. The probability of such a record to be achieved by someone born in the second half of the 19th century, in the world population documentarily eligible to age validation, and also in the G7 countries, can be calculated by applying some logistic and Gompertz mortality models to these populations, taken, respectively, from the age of 117 and of 100. This probability appears substantial, respectively, 7.1% and 4.7%, when using a four-parameter logistic model, which I validated on the observed survivals of centenarians until the age of 118. A 3-year interval with the second oldest is then expected. The known facts and documents constitute consistent evidence that JC died at 122: regular official records during her life, her verified memories from her 19th century life, her usage of specialized terms and of an abbreviation system specific to this period of time, photographs, her signature and handwriting, testimonies from numerous witnesses of her life, plus the expertise of gerontologists. Meanwhile, nothing contradicts her record: the daughter/mother identity swap hypothesis appears unrealistic and not supported by any evidence; especially no plausible motive can be found, on the contrary. The latest article, which defends this hypothesis, "Bayesian assessment of the longevity of JC," contains major errors, making its result subjective and invalid. The study of JC's genealogical tree on six generations, using longevity performance and total immediate ancestor longevity indicators, shows how, in two centuries, her ancestors have been living 10% longer on average at each generation, increasingly overperforming their French 25-year-old contemporaries, from around 7% in the early 18th century to 43% for her parents, and up to 56% for her older brother and 80% for herself, which suggests a progressive concentration of longevity factors. In addition to the hereditary factors, JC's personal overperformance suggests also some environmental factors, and indeed many are known. Further knowledge could be obtained by studying JC's existing blood and DNA samples: those could not only provide an additional proof of her authenticity, but more importantly could be of immense contribution for understanding deeper the factors and patterns of her longevity, and more generally the longevity and aging processes in humans in general as well.

中文翻译:

珍妮·卡门特(Jeanne Calment)独特的122年寿命:事实与因素;她家谱树中的长寿史。

珍妮·卡门特(Jeanne Calment's)的验证人类寿命无与伦比,为122年164天,比其他任何人都长3年以上,这让许多人感到惊讶。尽管她的案件被广泛接受为验证的黄金标准,但她的唱片年龄仍然引起一些人的怀疑。可以通过将一些logistic和Gompertz死亡率模型应用到19世纪下半叶,在有文件证明有资格进行年龄验证的世界人口中以及在G7国家中,实现这一记录的可能性来计算。这些人口分别来自117岁和100岁。使用四参数对数模型时,该概率分别显示为7.1%和4.7%,我对观察到的百岁老人的生存率进行了验证的118。然后,以3年为间隔,第二个最老。已知的事实和文件构成了JC于122岁去世的一贯证据:她一生中的定期正式记录,她对19世纪生活的经过验证的记忆,她在此期间使用的专门术语和缩写系统,照片,签名和手写,来自她一生的众多见证人的证词,以及老年医学专家的专业知识。同时,没有什么与她的记录相矛盾的是:女儿/母亲的身份互换假说似乎是不现实的,没有任何证据支持;相反,尤其是没有找到合理的动机。为这一假设辩护的最新文章“ JC寿命的贝叶斯评估”包含重大错误,使其结果主观且无效。JC的研究 世代相传的六代家谱树,使用了长寿表现和总的祖先直接寿命指标,显示出在两个世纪以来,她的祖先平均每代寿命延长了10%,在表现上超过了25岁的法国同龄人在18世纪初期,父母的这一比例约为7%,父母的比例为43%,哥哥的比例高达56%,她自己的比例高达80%,这表明长寿因素逐渐集中。除遗传因素外,JC的个人过分表现还暗示了一些环境因素,实际上许多因素是已知的。通过研究JC现有的血液和DNA样本,可以获得更多的知识:这些样本不仅可以提供其真实性的额外证据,
更新日期:2020-01-13
down
wechat
bug