Aim: This study aimed to evaluate concentration of plasma extracellular ubiquitin (UB) in coronary heart disease (CHD) patients and its correlation with the disease severity.Methods: Levels of UB and stromal cell-derived factor-1a (SDF-1a) were measured in 60 healthy controls and 67 CHD cases. Coronary atherosclerosis was assessed with Gensini scoring system. Spearman correlation was used to evaluate the correlation between UB and low-density lipoprotein cholesterol (LDL-C), C-reactive protein (CRP), creatine kinase-MB (CK-MB), cardiac troponin I (cTnI) or SDF-1a. The receiver-operating characteristic (ROC) curve was established to assess the predictive value of UB.Results: Plasma UB levels were significantly higher in CHD patients than in controls (p < .0001), and the levels in those with acute myocardial infarction (AMI) were higher than stable angina pectoris (SAP) and unstable angina pectoris (UAP) groups (both p < .01). UB was also positively correlated with Gensini score, CRP, CK-MB and cTnI in CHD. ROC analysis of UB showed that the area under the curve (AUC) were 0.711 (95%CI, 0.623-0.799) and 0.778 (95%CI, 0.666-0.890) for CHD and acute coronary syndrome (ACS), respectively. Plasma SDF-1a levels were elevated in CHD patients but showed no significant correlation with UB concentration or the severity of the disease.Conclusion: Plasma UB concentration was increased in CHD and the change of UB levels may reflect the progression of CHD.

中文翻译：

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在冠心病中细胞外泛素水平升高，并与疾病的严重程度有关。

目的：本研究旨在评估冠心病（CHD）患者血浆细胞外遍在蛋白（UB）的浓度及其与疾病严重程度的关系。方法：UB和基质细胞衍生因子1a（SDF-1a）的水平在60名健康对照者和67名CHD患者中进行了测量。用Gensini评分系统评估冠状动脉粥样硬化。Spearman相关性用于评估UB与低密度脂蛋白胆固醇（LDL-C），C反应蛋白（CRP），肌酸激酶-MB（CK-MB），心肌肌钙蛋白I（cTnI）或SDF-1a之间的相关性。建立了接受者操作特征（ROC）曲线以评估UB的预测价值。结果：CHD患者的血浆UB水平显着高于对照组（p <.0001），急性心肌梗死（AMI）患者的水平高于稳定型心绞痛（SAP）组和不稳定型心绞痛（UAP）组（均p <.01）。UB也与Gensini评分，CRP，CK-MB和cTnI呈正相关。UB的ROC分析显示，CHD和急性冠脉综合征（ACS）的曲线下面积（AUC）分别为0.711（95％CI，0.623-0.799）和0.778（95％CI，0.666-0.890）。结论：冠心病患者血浆SDF-1a水平升高，但与UB浓度或疾病严重程度无显着相关性。结论：CHD患者血浆UB浓度升高，UB水平的变化可能反映了CHD的进展。冠心病中的CK-MB和cTnI。UB的ROC分析显示，CHD和急性冠脉综合征（ACS）的曲线下面积（AUC）分别为0.711（95％CI，0.623-0.799）和0.778（95％CI，0.666-0.890）。结论：冠心病患者血浆SDF-1a水平升高，但与UB浓度或疾病严重程度无显着相关性。结论：CHD患者血浆UB浓度升高，UB水平的变化可能反映了CHD的进展。冠心病中的CK-MB和cTnI。UB的ROC分析显示，CHD和急性冠脉综合征（ACS）的曲线下面积（AUC）分别为0.711（95％CI，0.623-0.799）和0.778（95％CI，0.666-0.890）。结论：冠心病患者血浆SDF-1a水平升高，但与UB浓度或疾病严重程度无显着相关性。结论：CHD患者血浆UB浓度升高，UB水平的变化可能反映了CHD的进展。