Environmental, genetic, oxidative and biochemical factors play an important role in the atherosclerotic process. We investigated the association of serum fibroblast growth factor (FGF-23), klotho, fetuin-A, osteoprotegerin (OPG), osteopontin (OPN) and high-sensitive-CRP (Hs-CRP) markers with coronary artery disease and whether one was superior to others or not. A study group of 52 patients with coronary artery disease (CAD) and a control group of 30 patients with angiographically normal epicardial coronary arteries were included in the study. Serum FGF-23, klotho, fetuin-A, OPN, OPG and Hs-CRP marker levels were studied. Patients with CAD were classified in two groups as low (SYNTAX ≤22, n = 29) and moderate-high (SYNTAX ≥ 23, n = 23) according to anatomic SYNTAX score. FGF-23 (p = .033), klotho (p < .001), fetuin-A (p = .005) and OPG (p = .001) serum marker levels were significantly lower in CAD patients than the control group. Serum levels of FGF-23 (p = .012), klotho (p = .001), fetuin-A (p = .015) and OPG (p = 0.002) were significantly different between SYNTAX tertiles and control group. Klotho (p = .025, odd ratio (OR) = 0.542, 95% confidence interval (CI): 0.317–0.926) and HT (p = .004, OR = 34.598, 95%CI:1.054–1135.657) were the independent predictors of CAD presence. Serum klotho levels of 91.48 pmol/L predicts the presence of CAD with 60% sensitivity and 96.55% specificity (p < .001, area under curve = 0.864, 95% CI = 0.768, 0.931). We found that serum klotho level is an independent predictor of presence, extent and severity of CAD.

环境，遗传，氧化和生化因素在动脉粥样硬化过程中起重要作用。我们调查了血清成纤维细胞生长因子（FGF-23），klotho，胎球蛋白A，骨保护素（OPG），骨桥蛋白（OPN）和高敏感性CRP（Hs-CRP）标记与冠状动脉疾病的关系，以及是否是否优于他人。该研究包括52个冠心病（CAD）患者和30个血管造影正常心外膜冠状动脉患者的对照组。研究了血清FGF-23，klotho，胎球蛋白-A，OPN，OPG和Hs-CRP标记物水平。 根据解剖SYNTAX评分，将CAD患者分为低（SYNTAX≤22，n  = 29）和中高（SYNTAX≥23，n = 23）两组。FGF-23（p  = .033），klotho（p  <.001），fetuin-A（p  = .005）和OPG（p  = .001）的血清标志物水平在CAD患者中明显低于对照组。 SYNTAX三元组和对照组的血清FGF-23（p  = .012），klotho（p  = .001），胎球蛋白A（p  = .015）和OPG（p = 0.002）的水平显着不同。Klotho（p  = .025，奇数比（OR）= 0.542，95％置信区间（CI）：0.317–0.926）和HT（p = .004，或= 34.598，95％CI：1.054–1135.657）是CAD存在的独立预测因子。血清klotho水平为91.48 pmol / L可以预测CAD的敏感性为60％，特异性为96.55％（p  <.001，曲线下面积= 0.864，95％CI = 0.768，0.931）。我们发现血清klotho水平是CAD的存在，程度和严重性的独立预测因子。