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Antimicrobial and Wound Treatment Aspects of Micro- and Nanoformulations of Carboxymethyl, Dialdehyde, and TEMPO-Oxidized Derivatives of Cellulose: Recent Advances.
Macromolecular Bioscience ( IF 4.6 ) Pub Date : 2020-02-19 , DOI: 10.1002/mabi.201900362
Mehran Alavi 1 , Ali Nokhodchi 2, 3
Affiliation  

The remedy for infected chronic wounds such as diabetic foot ulcers is more complicated particularly in the case of patients with an inefficient immune system. Also, fighting against microbial infections in the wound site by available antibiotics may not be effective because of emerging antibiotic resistance properties among pathogenic bacteria and fungi. Recently, applications of micro‐ and nanoformulations of biomaterials have demonstrated improved therapeutic abilities for wound dressings. In this way, carboxymethyl, dialdehyde, and 2,2,6,6‐tetramethylpiperidine‐1‐oxyl‐oxidized celluloses are common biomaterials having outstanding physicochemical and therapeutic properties compared to unmodified cellulose. Therefore, in this review, recent progress in the field of wound healing and antimicrobial activities of these derivatives are presented and discussed.

中文翻译:

羧甲基,二醛和TEMPO氧化纤维素衍生物的微和纳米制剂的抗菌和伤口处理方面:最新进展。

对于感染的慢性伤口(如糖尿病足溃疡)的治疗更为复杂,尤其是在免疫系统效率低下的患者中。而且,由于在病原细菌和真菌中出现了新的抗生素抗性,因此通过可用的抗生素对抗伤口部位的微生物感染可能不是有效的。近来,生物材料的微和纳米制剂的应用已证明具有改善的伤口敷料的治疗能力。这样,与未改性的纤维素相比,羧甲基,二醛和2,2,6,6-四甲基哌啶-1-氧基氧化纤维素是具有出色理化和治疗性能的常见生物材料。因此,在这篇评论中,
更新日期:2020-02-19
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