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Trajectory of recurrent falls in post-menopausal breast cancer survivors and in matched cancer-free controls.
Breast Cancer Research and Treatment ( IF 3.8 ) Pub Date : 2020-02-19 , DOI: 10.1007/s10549-020-05576-8
Kathy Pan 1 , Roberta M Ray 2 , Jane A Cauley 3 , Aladdin H Shadyab 4 , Arti Hurria 5 , Rowan T Chlebowski 1
Affiliation  

PURPOSE Cross-sectional studies suggest that falls are prevalent among older breast cancer survivors. However, fall risk in this population has not been comprehensively examined. Therefore, we compared fall risk in older women post-breast cancer diagnosis to fall risk before cancer diagnosis and to risk in cancer-free matched controls. METHODS Among 2019 women in the Women's Health Initiative with localized breast cancer diagnosed at age ≥ 60 years with fall assessment data for 3 years pre-diagnosis and 3 years post-diagnosis, recurrent fall risk post-diagnosis was compared to risk in 2019 cancer-free controls matched by age, year of WHI entry, and baseline fall frequency. Generalized estimating equations under a logistic regression model were used to compare fall recurrence in breast cancer survivors and controls. Multi-variable models were adjusted for the matching factors, race/ethnicity, body mass index, and multiple chronic conditions. RESULTS In breast cancer survivors aged 70.8 years (mean) at diagnosis, over the 3-year pre-diagnosis interval, recurrent falls were reported by 18.5%. Over the 3-year post-diagnosis interval, recurrent falls were reported by 21.8% of breast cancer survivors and 20.0% of controls over the same time period (P = 0.27). Recurrent fall risk did not differ between breast cancer survivors and control women (OR 1.07, 95% CI 0.92-1.25), even after multi-variable adjustment. CONCLUSIONS In contrast to prior reports, older breast cancer survivors were not more likely to experience recurrent falls than age-matched counterparts. These findings underscore the need for incorporation of cancer-free control populations in survivorship studies to distinguish cancer sequelae from processes related to aging.

中文翻译:

绝经后乳腺癌幸存者和相匹配的无癌对照者复发率下降的轨迹。

目的横断面研究表明,摔倒在老年乳腺癌幸存者中很普遍。但是,该人群的跌倒风险尚未得到全面检查。因此,我们比较了老年妇女在乳腺癌诊断后的跌倒风险,癌症诊断前的跌倒风险和无癌匹配对照的风险。方法在妇女健康倡议中的2019年女性中,≥60岁被诊断出患有局部乳腺癌,并具有诊断前3年和诊断后3年的跌倒评估数据,将诊断后复发的跌倒风险与2019年癌症的风险进行了比较-免费控件,并根据年龄,WHI进入年份和基线跌倒频率进行匹配。在逻辑回归模型下的广义估计方程用于比较乳腺癌幸存者和对照组的秋季复发率。针对匹配因素,种族/民族,体重指数和多种慢性病,对多变量模型进行了调整。结果在诊断中年龄为70.8岁(平均)的乳腺癌幸存者中,在3年的诊断前间隔中,复发率下降了18.5%。在3年的诊断后间隔内,同期有21.8%的乳腺癌幸存者和20.0%的对照组复发复发(P = 0.27)。即使经过多变量调整,乳腺癌幸存者和对照妇女之间的再次跌倒风险没有差异(OR 1.07,95%CI 0.92-1.25)。结论与以前的报道相比,年龄较大的乳腺癌幸存者与年龄相匹配的乳腺癌幸存者跌倒的可能性更大。
更新日期:2020-02-19
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