Buriti oil is rich in monounsaturated fatty acids, carotenoids and tocopherols and it is used for the treatment of various diseases. One strategy to restructure the triglycerides is enzymatic interesterification and nanocarriers have been employed to improve the solubility, bioavailability and stability of active compounds. This work aims to investigate the in vitro cytotoxicity of this structured oil in nanoemulsions and nanostructured lipid carriers to expand the applicability of the crude oil. None of the samples had a cytotoxic effect on Caco-2 and HepG2 cell lines at the concentrations tested. Structured lipids acted protecting against oxidative stress and lipid peroxidation. Additionally, no consumption of glutathione has been observed in both cells, and the compounds present in buriti oil are possibly acting as antioxidants. Thus, nanoparticles prepared with interesterified buriti oil had low cytotoxicity and high oxidative stability, with great potential for future applications.

中文翻译：

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用结构化的Buriti油在Caco-2和HepG2细胞系中评估纳米脂质载体的细胞毒性。

Buriti油富含单不饱和脂肪酸，类胡萝卜素和生育酚，可用于治疗各种疾病。重组甘油三酸酯的一种策略是酶促酯交换，并且已经采用纳米载体来改善活性化合物的溶解性，生物利用度和稳定性。这项工作旨在研究这种结构油在纳米乳剂和纳米结构脂质载体中的体外细胞毒性，以扩大原油的适用性。在所测试的浓度下，没有样品对Caco-2和HepG2细胞系具有细胞毒性作用。结构化脂质起到保护作用，以抵抗氧化应激和脂质过氧化。另外，在两个细胞中均未观察到谷胱甘肽的消耗，并且存在于buriti油中的化合物可能充当抗氧化剂。从而，