Immune cells are characterized by diversity, specificity, plasticity, and adaptability-properties that enable them to contribute to homeostasis and respond specifically and dynamically to the many threats encountered by the body. Single-cell technologies, including the assessment of transcriptomics, genomics, and proteomics at the level of individual cells, are ideally suited to studying these properties of immune cells. In this review we discuss the benefits of adopting single-cell approaches in studying underappreciated qualities of immune cells and highlight examples where these technologies have been critical to advancing our understanding of the immune system in health and disease.

中文翻译：

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单细胞技术时代的免疫学。

免疫细胞具有多样性、特异性、可塑性和适应性特性，这些特性使它们能够促进体内平衡并对身体遇到的许多威胁做出特异性和动态的反应。单细胞技术，包​​括在单个细胞水平上评估转录组学、基因组学和蛋白质组学，非常适合研究免疫细胞的这些特性。在这篇综述中，我们讨论了采用单细胞方法研究免疫细胞被低估的特性的好处，并重点介绍这些技术对促进我们对健康和疾病免疫系统的理解至关重要的例子。