当前位置: X-MOL 学术Biol. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Biogenesis pathways of α-helical mitochondrial outer membrane proteins
Biological Chemistry ( IF 3.7 ) Pub Date : 2020-05-26 , DOI: 10.1515/hsz-2019-0440
Layla Drwesh 1 , Doron Rapaport 1
Affiliation  

Abstract Mitochondria harbor in their outer membrane (OM) proteins of different topologies. These proteins are encoded by the nuclear DNA, translated on cytosolic ribosomes and inserted into their target organelle by sophisticated protein import machineries. Recently, considerable insights have been accumulated on the insertion pathways of proteins into the mitochondrial OM. In contrast, little is known regarding the early cytosolic stages of their biogenesis. It is generally presumed that chaperones associate with these proteins following their synthesis in the cytosol, thereby keeping them in an import-competent conformation and preventing their aggregation and/or mis-folding and degradation. In this review, we outline the current knowledge about the biogenesis of different mitochondrial OM proteins with various topologies, and highlight the recent findings regarding their import pathways starting from early cytosolic events until their recognition on the mitochondrial surface that lead to their final insertion into the mitochondrial OM.

中文翻译:

α-螺旋线粒体外膜蛋白的生物发生途径

摘要 线粒体包含不同拓扑结构的外膜 (OM) 蛋白。这些蛋白质由核 DNA 编码,在胞质核糖体上翻译,并通过复杂的蛋白质输入机器插入其目标细胞器。最近,关于蛋白质插入线粒体 OM 的途径已经积累了相当多的见解。相比之下,关于它们生物发生的早期细胞质阶段知之甚少。通常假设分子伴侣在这些蛋白质在细胞质中合成后与它们相关联,从而使它们保持具有输入能力的构象并防止它们聚集和/或错误折叠和降解。在这篇综述中,我们概述了目前关于具有各种拓扑结构的不同线粒体 OM 蛋白的生物发生的知识,
更新日期:2020-05-26
down
wechat
bug