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Elevated cerebrospinal fluid sodium in hypertensive human subjects with a family history of Alzheimer's disease.
Physiological Genomics ( IF 4.6 ) Pub Date : 2020-01-21 , DOI: 10.1152/physiolgenomics.00093.2019
Lucas A C Souza 1, 2 , Fatima Trebak 1, 2 , Veena Kumar 3 , Ryousuke Satou 4 , Patrick G Kehoe 5 , Wei Yang 6 , Whitney Wharton 3 , Yumei Feng Earley 1, 2
Affiliation  

High salt (sodium) intake leads to the development of hypertension despite the fact that plasma sodium concentration ([Na+]) is usually normal in hypertensive human patients. Increased cerebrospinal fluid (CSF) sodium contributes to elevated sympathetic activity and high blood pressure (BP) in rodent models of hypertension. However, whether there is an increased accumulation of sodium in the CSF of humans with chronic hypertension is not well defined. Here, we investigated CSF [Na+] from hypertensive and normotensive human subjects with family histories of Alzheimer's disease in samples collected in a clinical trial, as spinal tap is not a routine clinical procedure for hypertensive patients. The [Na+] and osmolality in plasma and CSF were measured by flame photometry. Daytime ambulatory BP was monitored while individuals were awake. Participants were deidentified and data were analyzed in conjunction with a retrospective analysis of patient history and diagnosis. We found that CSF [Na+] was significantly higher in participants with high BP compared with normotensive participants; there was no difference in plasma [Na+], or plasma and CSF osmolality between groups. Subsequent multiple linear regression analyses controlling for age, sex, race, and body mass index revealed a significant positive correlation between CSF [Na+] and BP but showed no correlation between plasma [Na+] and BP. In sum, CSF [Na+] was higher in chronic hypertensive individuals and may play a key role in the pathogenesis of human hypertension. Collectively, our findings provide evidence for the clinical significance of CSF [Na+] in chronic hypertension in humans.

中文翻译:

具有阿尔茨海默氏病家族史的高血压人的脑脊液钠含量升高。

尽管事实上血浆钠浓度([Na +])在高血压人类患者中通常是正常的,但高盐(钠)摄入仍会导致高血压的发展。在高血压的啮齿动物模型中,脑脊液(CSF)钠的增加有助于交感神经活动和高血压(BP)的升高。然而,尚不清楚慢性高血压患者的脑脊液中钠的积累是否增加。在这里,我们从临床试验中收集的样本中调查了患有阿尔茨海默氏病家族史的高血压和血压正常人的CSF [Na +],因为脊柱抽搐不是高血压患者的常规临床程序。通过火焰光度法测量血浆和脑脊液中的[Na +]和重量克分子渗透浓度。当个人清醒时,监测白天的动态血压。确定参与者身份,并结合患者病史和诊断的回顾性分析对数据进行分析。我们发现与血压正常的参与者相比,血压高的参与者的CSF [Na +]明显更高;两组间血浆[Na +]或血浆和脑脊液渗透压的摩尔浓度无差异。随后对年龄,性别,种族和体重指数进行控制的多元线性回归分析显示,CSF [Na +]和BP之间存在显着的正相关,而血浆[Na +]和BP之间没有相关。总之,CSF [Na +]在慢性高血压个体中较高,可能在人类高血压的发病机理中起关键作用。总的来说,我们的发现为脑脊液[Na +]在人类慢性高血压中的临床意义提供了证据。
更新日期:2020-01-21
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