Introduction: Palmoplantar pustulosis (PPP) is a chronic, relapsing and refractory disease characterized by sterile pustules appearing on the palms and/or soles, accompanied by erythema, blistering, scales and/or keratinization. The overall burden of PPP in terms of its clinical impact, effect on patients and families, and economic consequences has not previously been investigated in a structured manner.Areas covered: A structured search focused on identification of studies in PPP using specific search terms in PubMed and EMBASE® from 2005 onwards, with additional back-referencing and pragmatic searches. Outcomes of interest included clinical burden, humanistic burden, and economic burden.Expert opinion: In cross-sectional studies, approximately 75% of all PPP patients suffer from active disease, with risk of relapse remaining constant over time. Patients' health-related quality of life is significantly impaired, as expected for a disease affecting hands and feet. Tools have been described that assess the clinical as well as patient-reported burden of PPP; their performance in larger cohorts and/or clinical trials remains to be investigated. The key data limitations identified include inconsistent definitions for characterizing remission/relapse, and limited humanistic and economic burden data; future studies are required to address these evidence gaps.

中文翻译：

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掌plant脓疱病的临床，人文和经济负担：结构性综述。

简介：掌plant脓疱病（PPP）是一种慢性，复发性和难治性疾病，其特征是在手掌和/或脚掌上出现无菌脓疱，并伴有红斑，起泡，鳞屑和/或角化。PPP的总体负担，包括其临床影响，对患者和家庭的影响以及经济后果，以前尚未以结构化的方式进行调查。研究范围：结构化搜索专注于使用PubMed中的特定搜索词来确定PPP中的研究以及2005年以后的EMBASE®，以及其他反向引用和实用搜索。感兴趣的结果包括临床负担，人文负担和经济负担。专家意见：在横断面研究中，所有PPP患者中约有75％患有活动性疾病，随着时间的推移复发的风险保持恒定。预期会影响手脚的疾病，严重影响患者的健康相关生活质量。已经描述了评估PPP临床以及患者报告负担的工具。它们在较大人群和/或临床试验中的表现仍有待研究。确定的关键数据局限性包括表征缓解/复发的不一致定义，以及有限的人文和经济负担数据；需要进一步的研究来解决这些证据的空白。确定的关键数据局限性包括表征缓解/复发的不一致定义，以及有限的人文和经济负担数据；需要进一步的研究来解决这些证据空白。确定的关键数据局限性包括表征缓解/复发的不一致定义，以及有限的人文和经济负担数据；需要进一步的研究来解决这些证据空白。