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Expression Profiles of MicroRNAs in Stem Cells Differentiation.
Current Pharmaceutical Biotechnology ( IF 2.8 ) Pub Date : 2020-07-31 , DOI: 10.2174/1389201021666200219092520
Hadi Rajabi 1 , Somayeh Aslani 1 , Alireza Abhari 1 , Davoud Sanajou 1
Affiliation  

Stem cells are undifferentiated cells and have a great potential in multilineage differentiation. These cells are classified into adult stem cells like Mesenchymal Stem Cells (MSCs) and Embryonic Stem Cells (ESCs). Stem cells also have potential therapeutic utility due to their pluripotency, self-renewal, and differentiation ability. These properties make them a suitable choice for regenerative medicine. Stem cells differentiation toward functional cells is governed by different signaling pathways and transcription factors. Recent studies have demonstrated the key role of microRNAs in the pathogenesis of various diseases, cell cycle regulation, apoptosis, aging, cell fate decisions. Several types of stem cells have different and unique miRNA expression profiles. Our review summarizes novel regulatory roles of miRNAs in the process of stem cell differentiation especially adult stem cells into a variety of functional cells through signaling pathways and transcription factors modulation. Understanding the mechanistic roles of miRNAs might be helpful in elaborating clinical therapies using stem cells and developing novel biomarkers for the early and effective diagnosis of pathologic conditions.



中文翻译:

MicroRNA在干细胞分化中的表达谱。

干细胞是未分化的细胞,在多系分化中具有很大的潜力。这些细胞分为成体干细胞,如间充质干细胞(MSCs)和胚胎干细胞(ESCs)。由于干细胞的多能性,自我更新和分化能力,它们也具有潜在的治疗用途。这些特性使它们成为再生医学的合适选择。干细胞向功能细胞的分化受不同的信号通路和转录因子控制。最近的研究表明,microRNA在各种疾病的发病机理,细胞周期调节,细胞凋亡,衰老,细胞命运决定中起着关键作用。几种类型的干细胞具有不同且独特的miRNA表达谱。我们的综述总结了miRNA在干细胞分化过程中的新调控作用,尤其是成年干细胞通过信号传导途径和转录因子调控而分化为多种功能性细胞。了解miRNA的机械作用可能有助于制定使用干细胞的临床疗法并开发新的生物标记物,以早期有效地诊断病理状况。

更新日期:2020-09-08
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