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Antibiotic Activity of Wickerhamomyces anomalus Mycocins on Multidrug-Resistant Acinetobacter baumannii.
Microbial Ecology ( IF 3.6 ) Pub Date : 2020-02-15 , DOI: 10.1007/s00248-020-01495-9
Daniele S B Junges 1 , Mateus F Delabeneta 1 , Lana Rubia B Rosseto 1 , Bruna L Nascimento 1 , Ana Paula Paris 1 , Cristiane Persel 1 , Eduardo A Loth 1 , Rita C G Simão 2 , Rafael A Menolli 2 , Claudete R Paula 3 , Rinaldo F Gandra 1
Affiliation  

To evaluate the susceptibility of multidrug-resistant Acinetobacter baumannii to mycocins produced by Wickerhamomyces anomalus and to verify the cytotoxicity of these compounds. Three culture supernatants of W. anomalus (WA40, WA45, and WA92), containing mycocins (WA40M1, WA45M2, and WA92M3), were tested on A. baumannii using broth microdilution methods, solid medium tests, and cytotoxicity tests in human erythrocytes and in Artemia saline Leach. W. anomalus was able to produce high antimicrobial mycocins, as even at high dilutions, they inhibited A. baumannii. In a solid medium, it was possible to observe the inhibition of A. baumannii, caused by the diffusion of mycocins between agar. Finally, the three supernatants were not cytotoxic when tested on human erythrocytes and Artemia salina. According to the evidence in this study, the mycocins of W. anomalus have been effective and could be used in the development of new antimicrobial substances.

中文翻译:

异常柳条菌对多药耐药鲍曼不动杆菌的抗菌活性。

评估多重耐药的鲍曼不动杆菌对由异常柳条产生的分枝杆菌的敏感性,并验证这些化合物的细胞毒性。使用肉汤微稀释法,固体培养基测试以及在人红细胞和人体内的细胞毒性测试,在鲍氏不动杆菌上测试了三种含有真菌素(WA40M1,WA45M2和WA92M3)的异常W.(WA40,WA45和WA92)培养上清液。卤虫盐水浸出。W. anomalus能够产生高抗菌力的真菌霉素,因为即使在高稀释度下,它们也会抑制鲍曼不动杆菌。在固体培养基中,有可能观察到由真菌素在琼脂之间扩散引起的鲍曼不动杆菌的抑制作用。最后,当在人红细胞和卤虫盐卤上测试时,这三种上清液没有细胞毒性。根据这项研究的证据,W的霉菌素。
更新日期:2020-04-22
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