The mitochondrial unfolded protein response (UPR^mt) is a mitochondrial protein quality control mechanism that is involved in many pathophysiological activities and maintains cellular homeostasis. The UPR^mt signaling pathway in both Caenorhabditis elegans and mammals has gained much attention in recent years. Many studies have reported the general function of UPR^mt, including the relationship between UPR^mt and longevity, survival, apoptosis, innate immunity, cancer growth, and neurodegenerative diseases. Stem cells are capable of self-renewing and differentiating, thus playing an important role in maintaining tissue homeostasis and tissue regeneration. Although the role and regulation of UPR^mt in somatic cells have been widely studied, the regulatory mechanism of UPR^mt in stem cells is not fully known. Thus, in this article, the regulatory role of UPR^mt in stem cell proliferation, cellular differentiation, and aging is reviewed. This review aims to provide novel insights for UPR^mt promoting stem cell rejuvenation and improving life span in mammals.

中文翻译：

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线粒体展开的蛋白质反应及其在干细胞中的作用。

线粒体未折叠蛋白反应（UPR ^mt）是一种线粒体蛋白质量控制机制，参与许多病理生理活动并维持细胞稳态。秀丽隐杆线虫和哺乳动物中的UPR ^mt信号转导途径近年来受到了广泛关注。许多研究报告了UPR ^mt的一般功能，包括UPR ^mt与寿命，存​​活率，细胞凋亡，先天免疫力，癌症生长和神经退行性疾病之间的关系。干细胞能够自我更新和分化，因此在维持组织稳态和组织再生中起着重要作用。虽然UPR的作用和调控^MT在体细胞中的UPR ^mt在干细胞中的调控机制尚未得到广泛研究。因此，在本文中，对UPR ^mt在干细胞增殖，细胞分化和衰老中的调节作用进行了综述。这篇综述旨在为UPR ^mt促进干细胞再生和改善哺乳动物的寿命提供新颖的见解。