Rabbits are commonly used for sciatic nerve injuries larger than 1.5 cm. This report provides insight into risks and benefits associated with using rabbit models in sciatic nerve injury models and proposes interventions that researchers can use to prevent experimental complications. Fifty-six rabbits from a sciatic nerve injury study that involved a 40 mm sciatic nerve injury were analyzed to examine postoperative complication rates. Autophagy of the phalanges and plantar pressure ulcer development were the most common and serious complications faced. These complications led to 23.2% (n = 13) of rabbits not being used for data in the original experiment due to euthanasia outside of intended postoperative time points. This increased the cost needed to complete the experiment by $25,038.44. It is our recommendation that alternative models be used instead of rabbits for sciatic nerve injuries. If rabbits must be used, a treatment protocol for preventing autophagy and pressure ulcers is outlined below.

中文翻译：

---

兔坐骨神经损伤模型：预期结果。

兔子通常用于坐骨神经损伤大于1.5厘米。该报告提供了在坐骨神经损伤模型中使用兔模型相关的风险和收益的见解，并提出了研究人员可以用来预防实验并发症的干预措施。对坐骨神经损伤研究中涉及40毫米坐骨神经损伤的56只兔子进行了分析，以检查术后并发症发生率。指骨自噬和足底压疮的发展是最常见和最严重的并发症。这些并发症导致23.2％（n = 13）的兔子由于预期的术后时间点之外的安乐死而没有用于原始实验的数据。完成实验所需的费用增加了25,038.44美元。我们建议使用替代模型代替坐骨神经损伤兔。如果必须使用兔子，则下面概述了预防自噬和压疮的治疗方案。