The prevalence of allergic diseases in the African continent has received limited attention with the allergic diseases due to fungal allergens being among the least studied. This lead to the opinion being that the prevalence of allergic disease is low in Africa. Recent reports from different African countries indicate that this is not the case as allergic conditions are common and some; particularly those due to fungal allergens are increasing in prevalence. Thus, there is need to understand both the aetiology and pathogenies of these diseases, particularly the neglected fungal allergic diseases. This review addresses currently available knowledge of fungal-induced allergy, disease pathogenesis comparing findings from human versus experimental mouse studies of fungal allergy. The review discusses the potential role of the gut mycobiome and the extent to which this is relevant to fungal allergy, diagnosis and human health.

中文翻译：

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非洲人口中与真菌有关的疾病和过敏的发病机制：证据和知识差距的状态。

由于对真菌过敏原的研究最少，因此非洲大陆过敏性疾病的流行受到了有限的关注。这导致人们认为非洲的过敏性疾病患病率较低。来自非洲不同国家的最新报告表明，情况并非如此，因为过敏性疾病很普遍，有些情况也是如此。特别是那些由于真菌过敏原引起的流行。因此，需要了解这些疾病的病因和病原学，尤其是被忽视的真菌过敏性疾病。这篇综述通过比较人类和实验小鼠对真菌过敏的研究结果，探讨了真菌诱导的过敏，疾病发病机理的当前可用知识。