The concept of trained immunity refers to remodelling of the monocyte and macrophage metabolic and epigenetic landscape, conferring an amplified inflammatory response upon secondary stimulation. This effect is typically modelled in vitro by stimulating monocytes with either Bacillus Calmette Guerin (BCG) or β-Glucan for 24 hr, before subsequent stimulation with LPS or Pam-3-Cys (P3C) as a secondary stimulus 6 days later. Here, we focus on a recent paper which interrogated the role of the anti-inflammatory TLR, TLR10, on trained immunity. Using both an in vitro model of trained immunity, and analysis of BCG vaccinated individuals, the authors interestingly demonstrate that, despite its ability to regulate aspects of innate immunity, TLR10 does not have a significant role in this process.

中文翻译：

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恢复训练或过度训练？TLR10对单核细胞适应性的贡献。

训练有素的免疫力的概念是指单核细胞和巨噬细胞代谢和表观遗传结构的重塑，在二次刺激后赋予放大的炎症反应。通常在体外通过用卡介苗芽孢杆菌（BCG）或β-葡聚糖刺激单核细胞24小时，然后在6天后再用LPS或Pam-3-Cys（P3C）进行二次刺激来模拟这种作用。在这里，我们集中于最近的一篇论文，该论文审问了抗炎TLR，TLR10对训练后的免疫的作用。使用受过训练的免疫力的体外模型和对接种卡介苗的人进行分析，作者有趣地证明，尽管TLR10具有调节先天免疫力的能力，但在此过程中并未发挥重要作用。