The changes in neuronal firing activity in the primary motor cortex (M1) and supplementary motor area (SMA) were compared in monkeys rendered parkinsonian by treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. The neuronal dynamic was characterized using mathematical tools defined in different frameworks (rate, oscillations or complex patterns). Then, and for each cortical area, multivariate and discriminate analyses were further performed on these features to identify those important to differentiate between the normal and the pathological neuronal activity. Our results show a different order in the importance of the features to discriminate the pathological state in each cortical area which suggests that the M1 and the SMA exhibit dissimilarities in their neuronal alterations induced by parkinsonism. Our findings highlight the need for multiple mathematical frameworks to best characterize the pathological neuronal activity related to parkinsonism. Future translational studies are warranted to investigate the causal relationships between cortical region-specificities, dominant pathological hallmarks and symptoms.

中文翻译：

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帕金森病不同地影响猴子初级和补充运动区的单个神经元活动：线性和非线性域的研究

在用 1-甲基-4-苯基-1,2,3,6-四氢吡啶治疗导致帕金森病的猴子中，比较了初级运动皮层 (M1) 和辅助运动区 (SMA) 中神经元放电活动的变化。使用在不同框架（速率、振荡或复杂模式）中定义的数学工具来表征神经元动态。然后，对于每个皮层区域，进一步对这些特征进行多变量和判别分析，以确定区分正常和病理神经元活动的重要特征。我们的结果表明，区分每个皮质区域病理状态的特征的重要性顺序不同，这表明 M1 和 SMA 在帕金森症引起的神经元改变中表现出不同。我们的研究结果强调需要多种数学框架来最好地描述与帕金森病相关的病理性神经元活动。未来的转化研究有必要调查皮质区域特异性、主要病理特征和症状之间的因果关系。