OBJECTIVE To investigate the relationship of 1-h postload plasma glucose during the oral glucose tolerance test with the severity of coronary artery lesions and risk of 1-year re-admission in coronary heart disease patients with normal glucose tolerance. METHODS A total of 266 consecutive coronary heart disease patients who underwent coronary angiography and had normal glucose tolerance confirmed by oral glucose tolerance test during hospitalization were prospectively enrolled and followed in two groups according to the 1-h postload plasma glucose cut-off point (1-h postload plasma glucose <155 mg/dL, n = 149 and 1-h postload plasma glucose ⩾155 mg/dL, n = 117). Angiographic severity was assessed by number of diseased vessels, lesion morphology and Gensini score. The risk of 1-year re-admission with adverse cardiovascular events after discharge was analysed. RESULTS Subjects with a 1-h postload plasma glucose ⩾155 mg/dL had higher incidence of multivessel disease and complex lesions, Gensini score and risk of 1-year re-admission than subjects with a 1-h postload plasma glucose <155 mg/dL (all p < 0.05). In the stepwise multivariate regression analysis, 1-h postload plasma glucose was the major determinant of the Gensini score. Subgroup analyses by sex showed that men with a 1-h postload plasma glucose ⩾155 mg/dL had higher incidence of complex lesions and risk of 1-year re-admission than men with a 1-h postload plasma glucose <155 mg/dL (all p < 0.05). CONCLUSION Coronary heart disease patients with normal glucose tolerance and elevated 1-h postload plasma glucose levels had a greater severity of coronary artery lesions and an increased risk of re-admission with adverse cardiovascular events, particularly in men.

中文翻译：

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负荷后1小时血浆葡萄糖水平升高表明冠心病患者的冠状动脉病变严重程度更高，再次入院1年的风险更高。

目的探讨糖耐量正常的冠心病患者口服葡萄糖耐量试验中负荷后1小时血糖与冠状动脉病变严重程度和1年再入院风险的关系。方法回顾性分析266例接受冠状动脉造影检查并在住院期间经口服糖耐量试验证实其糖耐量正常的连续性冠心病患者，并根据负荷后1小时血浆葡萄糖截止点将其分为两组（1 -h负荷后血浆葡萄糖<155 mg / dL，n = 149； 1-h负荷后血浆葡萄糖≤155mg / dL，n = 117）。通过病变血管的数量，病变形态和Gensini评分评估血管造影的严重性。分析了出院后一年再次入院并伴有不良心血管事件的风险。结果负荷后1小时血浆葡萄糖<155 mg / dL的受试者发生多支血管疾病和复杂病变，Gensini评分和1年再次入院的风险较高，负荷后1小时血浆葡萄糖<155 mg / d dL（所有p <0.05）。在逐步多元回归分析中，负荷后1小时的血浆葡萄糖是Gensini评分的主要决定因素。按性别进行的亚组分析显示，负荷后1小时血浆葡萄糖⩾155mg / dL的男性比负荷后1小时血浆葡萄糖<155 mg / dL的男性具有更高的复杂病变发生率和一年再入院风险（所有p <0.05）。