Aim: A novel folated pluronic F127 (FA-F127) was synthesised, so as to modify liposomes with FA group on the surface, and evaluate the effects of FA-F127 modification on the properties of the modified liposomes.Methods: FA was linked to one end of pluronic F127, via the terminal OH group, to obtain FA-F127 and the structure was characterised. FA-F127 modified curcumin liposomes (cur-FA-F127-Lps) were prepared. The physicochemical characteristics of cur-FA-F127-Lps, including morphology and particle size, were studied. The in vitro cytotoxicity of cur-FA-F127-Lps against KB cancer cells was determined by MTT tests.Results: The effects of FA-F127 modification on the average particle size, PDI, curcumin encapsulation efficiency and microstructure were not significant. Compared with nonfolated F127 liposomes (cur-F127-Lps), cur-FA-F127-Lps exhibited significantly higher cytotoxicity towards KB cells.Conclusions: Folic acid modified liposomes provide a novel strategy to improve the chemotherapeutic efficacy of hydrophobic bioactive compounds.

中文翻译：

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用于递送姜黄素的新型叶酸普朗尼克F127修饰脂质体：制备，释放和细胞毒性。

目的：合成新型叶酸普鲁尼克酮F127（FA-F127），以表面具有FA基团的脂质体进行修饰，并评价FA-F127修饰对修饰脂质体性能的影响。普朗尼克F127的一端通过OH端基获得FA-F127，并对其结构进行了表征。制备FA-F127修饰的姜黄素脂质体（cur-FA-F127-Lps）。研究了cur-FA-F127-Lps的理化特性，包括形态和粒径。MTT法检测cur-FA-F127-Lps对KB癌细胞的体外细胞毒性。结果：FA-F127修饰对平均粒径，PDI，姜黄素包封率和微观结构的影响不显着。与非叶酸F127脂质体（cur-F127-Lps）相比，