BACKGROUND Previous studies have shown that hyperbaric oxygen therapy (HBOT) can improve the motor functions and memory of post-stroke patients in the chronic stage. OBJECTIVE The aim of this study is to evaluate the effects of HBOT on overall cognitive functions of post-stroke patients in the chronic stage. The nature, type and location of the stroke were investigated as possible modifiers. METHODS A retrospective analysis was conducted on patients who were treated with HBOT for chronic stroke (>3 months) between 2008-2018. Participants were treated in a multi-place hyperbaric chamber with the following protocols: 40 to 60 daily sessions, 5 days per week, each session included 90 min of 100% oxygen at 2 ATA with 5 min air brakes every 20 minutes. Clinically significant improvements (CSI) were defined as > 0.5 standard deviation (SD). RESULTS The study included 162 patients (75.3% males) with a mean age of 60.75±12.91. Of them, 77(47.53%) had cortical strokes, 87(53.7%) strokes were located in the left hemisphere and 121 suffered ischemic strokes (74.6%).HBOT induced a significant increase in all the cognitive function domains (p < 0.05), with 86% of the stroke victims achieving CSI. There were no significant differences post-HBOT of cortical strokes compared to sub-cortical strokes (p > 0.05). Hemorrhagic strokes had a significantly higher improvement in information processing speed post-HBOT (p < 0.05). Left hemisphere strokes had a higher increase in the motor domain (p < 0.05). In all cognitive domains, the baseline cognitive function was a significant predictor of CSI (p < 0.05), while stroke type, location and side were not significant predictors. CONCLUSIONS HBOT induces significant improvements in all cognitive domains even in the late chronic stage. The selection of post-stroke patients for HBOT should be based on functional analysis and baseline cognitive scores rather than the stroke type, location or side of lesion.

中文翻译：

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高压氧疗法可改善中风后患者的神经认知功能-一项回顾性分析。

背景技术以前的研究表明，高压氧治疗（HBOT）可以改善慢性期卒中后患者的运动功能和记忆力。目的本研究的目的是评估HBOT对慢性期卒中后患者总体认知功能的影响。研究了笔画的性质，类型和位置，将其作为可能的修饰符。方法对2008-2018年间接受HBOT治疗的慢性卒中（> 3个月）患者进行回顾性分析。参加者在多位置高压舱中接受以下治疗：每天40至60次疗程，每周5天，每次疗程包括90％的100％氧气（在2 ATA下），每20分钟5分钟的空气制动。临床上的显着改善（CSI）定义为> 0.5标准差（SD）。结果该研究包括162例患者（男性占75.3％），平均年龄为60.75±12.91。其中77例（47.53％）为皮质卒中，87例（53.7％）位于左半球，121例缺血性卒中（74.6％）。HBOT诱导所有认知功能域显着增加（p <0.05） ，其中86％的中风受害者获得了CSI。HBOT后皮质卒中与皮质下卒中相比无显着差异（p> 0.05）。出血性中风在HBOT后的信息处理速度方面有显着更高的改善（p <0.05）。左半球卒中在运动区域有较高的增加（p <0.05）。在所有认知领域，基线认知功能均是CSI的重要预测指标（p <0.05），而卒中类型，位置和侧面则不是重要的预测指标。结论即使在慢性晚期，HBOT也会在所有认知领域显着改善。中风后HBOT患者的选择应基于功能分析和基线认知评分，而不是中风类型，部位或病变侧。