Objective: This meta-analysis was designed to investigate the association between interferon-gamma (IFN-γ) polymorphisms and occurrence risk of aplastic anemia.Methods: Literature search was conducted in PubMed, Embase and Cochrane Library up to April 2018. The pooled odds ratios (ORs) and 95% confidence interval (CI) were calculated by R 3.12.Results: Total five studies with 304 aplastic anemia patients and 588 controls were included. The statistically significant results were found in the following models: allele genetic model (T vs A: OR = 2.1749, 95% CI = 1.6825-2.8114, P < 0.01), additive genetic model (TA vs AA: OR = 2.1071, 95% CI = 1.3962-3.1799, P < 0.01; TT vs AA: OR = 4.5788, 95% CI = 2.6606-7.8797, P < 0.01), recessive genetic model (TT vs AA + TA: OR = 2.5579, 95% = 1.6680-3.9226, P < 0.01), dominant genetic model (TT + TA vs AA: OR = 2.5599, 95% = 1.7424-3.7611, P < 0.01), the results suggested that the increased occurrence risk of aplastic anemia is significantly associated with the IFN-γ polymorphism.Conclusions: Patients with IFN-γ genotype carrying allele T have higher occurrence risk of aplastic anemia.

中文翻译：

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干扰素-γ（INF-γ）单核苷酸多态性+874（T / A）与再生障碍性贫血发生风险之间的关系：荟萃分析。

目的：本荟萃分析旨在研究干扰素-γ（IFN-γ）多态性与再生障碍性贫血发生风险之间的关系。方法：截至2018年4月，在PubMed，Embase和Cochrane图书馆中进行文献检索。通过R 3.12计算比率（OR）和95％置信区间（CI）。结果：包括对304例再生障碍性贫血患者和588例对照的五项研究。在以下模型中发现了具有统计学意义的结果：等位基因遗传模型（T vs A：OR = 2.1749，95％CI = 1.6825-2.8114，P <0.01），加性遗传模型（TA vs AA：OR = 2.1071，95％ CI = 1.3962-3.1799，P <0.01; TT vs AA：OR = 4.5788，95％CI = 2.6606-7.8797，P <0.01），隐性遗传模型（TT vs AA + TA：OR = 2.5579，95％= 1.6680- 3.9226，P <0.01），