Alcohol dehydrogenases (ADHs) catalyze the reversible reduction of a carbonyl group to its corresponding alcohol. ADHs are widely employed for organic synthesis due to their lack of harm to the environment, broad substrate acceptance, and high enantioselectivity. This review focuses on the impact and relevance of ADH enantioselectivities on their biotechnological application. Stereoselective ADHs are beneficial to reduce challenging ketones such as ketones owning two bulky substituents or similar-sized substituents to the carbonyl carbon. Meanwhile, in cascade reactions, non-stereoselective ADHs can be utilized for the quantitative oxidation of racemic alcohol to ketone and dynamic kinetic resolution.

中文翻译：

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酒精脱氢酶对映选择性对生物技术应用的影响和相关性。

醇脱氢酶（ADHs）催化羰基可逆还原为相应的醇。由于ADH对环境无害，对底物的广泛接受和高对映选择性，它们被广泛用于有机合成。这篇综述着重于ADH对映选择性对其生物技术应用的影响和相关性。立体选择性ADH有利于减少具有挑战性的酮，例如具有两个大的取代基或与羰基碳具有相似大小的取代基的酮。同时，在级联反应中，非立体选择性ADH可用于外消旋醇定量氧化为酮和动态动力学拆分。