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The Association of Oxytocin Receptor Gene (OXTR) Polymorphisms with Antisocial Behavior: A Meta-analysis.
Behavior Genetics ( IF 2.6 ) Pub Date : 2020-02-14 , DOI: 10.1007/s10519-020-09996-6 Holly E Poore 1 , Irwin D Waldman 1
Behavior Genetics ( IF 2.6 ) Pub Date : 2020-02-14 , DOI: 10.1007/s10519-020-09996-6 Holly E Poore 1 , Irwin D Waldman 1
Affiliation
Evidence suggests that the Oxytocin Receptor Gene (OXTR) influences human social cognition and behavior. OXTR has been investigated in relation to antisocial behavior, but studies examining this association have produced varying results in terms of the magnitude and significance of the association as well as which SNPs are implicated. This meta-analysis, based on 15 samples in 12 studies with a total sample of 12,236 individuals, examined the overall effects and consistency of associations between eight SNPs in OXTR and antisocial behavior. Random effects models identified a significant association between rs237887 and antisocial behavior (r = 0.06, p = 0.002) based on six studies that included a total of 6278 individuals. Sensitivity analyses suggest that these results were robust to exclusion of any individual study and publication bias. Nevertheless, the high levels of heterogeneity and quality control concerns with the original publications lead us to interpret this one significant finding with caution. We conclude that the available literature does not rule out, nor strongly support, an effect of OXTR on antisocial behavior.
中文翻译:
催产素受体基因(OXTR)多态性与反社会行为的关联:荟萃分析。
有证据表明催产素受体基因(OXTR)影响人类的社会认知和行为。已经对OXTR的反社会行为进行了研究,但是研究该关联的研究在关联的大小和意义以及涉及SNP方面产生了不同的结果。这项荟萃分析基于12项研究中的15项样本,共计12,236名个体,检查了OXTR中8个SNP与反社会行为之间关联的整体效果和一致性。随机效应模型基于六项研究(共6278名个体)确定了rs237887与反社会行为之间的显着关联(r = 0.06,p = 0.002)。敏感性分析表明,这些结果对于排除任何单独的研究和发表偏倚是有力的。然而,原始出版物对异质性和质量控制的高度关注导致我们谨慎地解释这一重要发现。我们得出结论,现有文献不排除也不强烈支持OXTR对反社会行为的影响。
更新日期:2020-04-20
中文翻译:
催产素受体基因(OXTR)多态性与反社会行为的关联:荟萃分析。
有证据表明催产素受体基因(OXTR)影响人类的社会认知和行为。已经对OXTR的反社会行为进行了研究,但是研究该关联的研究在关联的大小和意义以及涉及SNP方面产生了不同的结果。这项荟萃分析基于12项研究中的15项样本,共计12,236名个体,检查了OXTR中8个SNP与反社会行为之间关联的整体效果和一致性。随机效应模型基于六项研究(共6278名个体)确定了rs237887与反社会行为之间的显着关联(r = 0.06,p = 0.002)。敏感性分析表明,这些结果对于排除任何单独的研究和发表偏倚是有力的。然而,原始出版物对异质性和质量控制的高度关注导致我们谨慎地解释这一重要发现。我们得出结论,现有文献不排除也不强烈支持OXTR对反社会行为的影响。