The feeling of happiness is beneficial for both mental and physical health. Based on the findings of previous studies that reported that the insular cortex is a crucial region for subjective feelings, including happiness, in this study, we further identified the subregion of the insula and its functional connectivity associated with subjective well-being (SWB). Using an iterative seed-target-seed approach, we labelled the posterior, dorsal, and ventral anterior insular regions of interest (ROIs) and evaluated the association between functional connectivity of each of these insular ROIs and the self-reported SWB in a group of 75 healthy elderly adults. We demonstrated that the functional connectivity of the dorsal anterior insula (dAI) was significantly correlated with SWB. This relationship was negative and unique for the functional connectivity of left dAI with specific regions from the default-mode network, including the anterior medial prefrontal cortex and inferior parietal lobe. Our result suggested a functional connectivity network of the left dAI with specific DMN brain regions, suggesting the neural basis of SWB.

中文翻译：

---

主观幸福感与背侧前岛叶的功能连接网络有关。

幸福的感觉对身心健康都有好处。根据先前研究的结果，岛叶皮层是主观感受（包括幸福感）的关键区域，在本研究中，我们进一步确定了岛叶的子区域及其与主观幸福感 (SWB) 相关的功能连接。使用迭代种子-目标-种子方法，我们标记了后部、背侧和腹侧前岛感兴趣区域 (ROI)，并评估了这些岛 ROI 中每一个的功能连通性与一组自我报告的 SWB 之间的关联。 75 名健康老年人。我们证明了背侧前岛叶 (dAI) 的功能连接与 SWB 显着相关。这种关系对于左侧 dAI 与来自默认模式网络的特定区域（包括前内侧前额叶皮层和下顶叶）的功能连接是负面的和独特的。我们的结果表明具有特定 DMN 大脑区域的左侧 dAI 的功能连接网络，表明 SWB 的神经基础。