PURPOSE The purpose of this study was to evaluate the antithrombogenic effects of poly-2-methoxyethylacrylate (PMEA) coating applied to the internal surfaces of the port-catheter system to prevent thrombotic occlusion. MATERIALS AND METHODS PMEA coating was applied to the inner surfaces of the entire system, including the chamber, catheter, and connecting stem. PMEA-coated and uncoated port-catheter systems were each filled with fresh human blood for 1 or 3 h and then flushed with saline. Volumes of residual thrombi in the system and protein in the catheter were then compared. RESULTS Saline flushing of the PMEA-coated port-catheter system expelled all visually recognizable thrombi, leaving no unremovable adhesions. In contrast, the uncoated port showed thrombi adherent to the inner surfaces and incomplete expulsion with flushing. Mean (± standard deviation) residual thrombus mass was significantly lower in PMEA-coated port-catheter systems (20.5 ± 6.2 mg) than in uncoated systems (230.3 ± 92.5 mg; p < 0.01). Mean residual protein was likewise significantly lower in PMEA-coated systems (20.5 ± 6.2 mg) than in uncoated systems (230.3 ± 92.5 mg; p < 0.01). CONCLUSIONS PMEA coating on a central venous port-catheter system decreased accumulation and facilitated flushing of thrombi from the system by flushing, as compared with the uncoated system. PMEA-coated central venous port-catheter systems appear relatively antithrombotic compared to uncoated systems.

中文翻译：

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评估聚-2-甲氧基乙基丙烯酸酯涂层中央静脉输液导管系统的抗血栓形成性。

目的这项研究的目的是评估涂在导管系统内表面的聚-2-甲氧基乙基丙烯酸酯（PMEA）涂层的抗血栓形成作用，以防止血栓闭塞。材料与方法将PMEA涂层施加到整个系统的内表面，包括腔室，导管和连接杆。将PMEA涂层和未涂层​​的端口导管系统分别充满新鲜的人血1或3 h，然后用盐水冲洗。然后比较系统中残留的血栓量和导管中的蛋白质。结果PMEA涂层导管系统的盐水冲洗排除了所有肉眼可识别的血栓，没有留下不可去除的粘连。相反，未涂覆的端口显示血栓粘附在内表面上，并且冲洗后排出不完全。在PMEA涂层的导管系统中，平均（±标准偏差）残余血栓质量显着低于未涂层的系统（230.3±92.5 mg； p <0.01）。同样，在PMEA包被的系统中（20.5±6.2 mg），平均残留蛋白也显着低于未包被的系统（230.3±92.5 mg； p <0.01）。结论与未涂覆的系统相比，中央静脉端口导管系统上的PMEA涂层减少了积聚并通过冲洗促进了系统中血栓的冲洗。与未涂层的系统相比，PMEA涂层的中心静脉端口导管系统显得相对抗血栓形成。同样，在PMEA涂层系统中（20.5±6.2 mg），平均残留蛋白质显着低于未涂层系统（230.3±92.5 mg； p <0.01）。结论与未涂覆的系统相比，中央静脉端口导管系统上的PMEA涂层减少了积聚并通过冲洗促进了系统中血栓的冲洗。与未涂层的系统相比，PMEA涂层的中心静脉端口导管系统显得相对抗血栓形成。同样，在PMEA涂层系统中（20.5±6.2 mg），平均残留蛋白质显着低于未涂层系统（230.3±92.5 mg； p <0.01）。结论与未涂覆的系统相比，中央静脉端口导管系统上的PMEA涂层减少了积聚并通过冲洗促进了系统中血栓的冲洗。与未涂覆的系统相比，PMEA涂覆的中心静脉端口导管系统显得相对抗血栓形成。