Recently, a number of long noncoding RNAs (lncRNAs) have been reported to play significant roles in human tumorigenesis. However, only few gastric cancer related lncRNAs have been well characterized. Here, we identified one lncRNA HRCEG, whose expression was decreased in the gastric cancer tissues compared with adjacent normal tissues. Overexpression of HRCEG significantly promoted cell apoptosis and inhibited cell proliferation. Importantly, we demonstrated that HRCEG levels inversely correlated with EMT process and HRCEG was regulated by the histone deacetylase 1 (HDAC1) in gastric cancer. These findings suggest that HRCEG might be regulated by HDAC1 to inhibit gastric cancer progress and metastatic capability via EMT pathway.

最近，据报道许多长的非编码RNA（lncRNA）在人类肿瘤发生中起重要作用。但是，只有少数胃癌相关的lncRNAs得到了很好的表征。在这里，我们确定了一个lncRNA HRCEG，与邻近的正常组织相比，其在胃癌组织中的表达降低。HRCEG的过表达显着促进细胞凋亡并抑制细胞增殖。重要的是，我们证明了胃癌中HRCEG水平与EMT过程呈负相关，并且HRCEG受组蛋白脱乙酰基酶1（HDAC1）调控。这些发现提示HDACG可能受到HDAC1的调控，以抑制胃癌的进展和通过EMT途径的转移能力。