Recently, increasing evidence showed that circular RNAs (circRNAs) play critical roles in tumor progression. However, the roles of hsa_circ_0062389 in non-small cell lung cancer (NSCLC) development remain unclear. In the present study, hsa_circ_0062389 expression was significantly increased in NSCLC tissues and cell lines. High hsa_circ_0062389 expression was associated with advanced TNM stage and lymph-node metastasis. Function assays showed that hsa_circ_0062389 suppression reduced NSCLC cells proliferation and arrested cell cycle in G0/G1 phase. In mechanism, hsa_circ_0062389 directly interacted with miR-103a-3p in NSCLC, and CCNE1 acted as a target of miR-103a-3p. Furthermore, rescue assays showed that miR-103a-3p suppression or CCNE1 overexpression abolished the effects of hsa_circ_0062389 suppression on lung cancer cells progression. Therefore, our results showed that the hsa_circ_0062389/miR-103a-3p/CCNE1 axis might contribute to the tumorigenesis of NSCLC, which provided a new strategy for cancer treatment.

最近，越来越多的证据表明，环状RNA（circRNA）在肿瘤进展中起关键作用。但是，hsa_circ_0062389在非小细胞肺癌（NSCLC）发育中的作用仍不清楚。在本研究中，hsa_circ_0062389表达在NSCLC组织和细胞系中显着增加。hsa_circ_0062389高表达与晚期TNM分期和淋巴结转移有关。功能测定表明，hsa_circ_0062389抑制作用抑制了NSCLC细胞的增殖，并使细胞周期停滞在G0 / G1期。在机制上，hsa_circ_0062389与NSCLC中的miR-103a-3p直接相互作用，而CCNE1充当miR-103a-3p的靶标。此外，救援试验表明，miR-103a-3p抑制或CCNE1过表达消除了hsa_circ_0062389抑制对肺癌细胞进展的影响。