Exposure to ethanol during pregnancy is the cause of fetal alcohol spectrum disorder. The function of L1 cell adhesion molecule (L1), critical for proper brain development, is dependent on detergent‐resistant membrane microdomains (DRM). Ethanol at low concentrations disrupts L1 function measured by inhibition of downstream signaling and alterations in L1‐DRM distribution in cerebellum in vivo and in cerebellar granule neurons (CGN) in vitro. We have previously shown that choline pretreatment of CGN partially prevents ethanol toxicity through improving L1 function in vitro. Here we show that choline supplementation reduces the impact of ethanol on L1 in cerebellum in vivo.

中文翻译：

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胆碱改善乙醇诱导的酪氨酸磷酸化改变和 L1 细胞粘附分子在体内耐洗涤剂膜微区的分布。

怀孕期间接触乙醇是胎儿酒精谱系障碍的原因。L1 细胞粘附分子 (L1) 的功能对大脑的正常发育至关重要，它依赖于耐洗涤剂的膜微域 (DRM)。低浓度乙醇会破坏 L1 功能，通过抑制下游信号和改变小脑体内 L1-DRM 分布和体外小脑颗粒神经元 (CGN) 的 L1-DRM 分布来衡量。我们之前已经表明，CGN 的胆碱预处理通过改善体外 L1 功能部分防止乙醇毒性。在这里，我们表明补充胆碱可降低乙醇对体内小脑 L1 的影响。