BACKGROUND Treating patients with inflammatory joint diseases (rheumatoid arthritis, psoriatic arthritis) according to established treatment algorithms often requires the simultaneous use of three or more medications to relieve symptoms and prevent long-term joint damage as well as disability. OBJECTIVE To assess and give an overview on drug-drug interactions in the pharmacotherapy of inflammatory joint diseases with regards to their clinical relevance. METHODS All possible drug combinations were evaluated using three commercially available drug interaction programs. In those cases where only limited/no data were found, a comprehensive hand search of Pubmed was carried out. Finally, the drug-drug interactions of all possible combinations were classified according to evidence-based medicine and a specifically generated relevance-based system. RESULTS All three interaction software programs showed consistent results. All detected interactions were combined in clearly structured tables. CONCLUSION A concise overview on drug-drug interactions is given. Especially in more sophisticated cases extensive knowledge of drug interactions supports optimisation of therapy and results in improved patient safety.

中文翻译：

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在类风湿关节炎和银屑病关节炎的治疗中的药物相互作用。

背景技术根据已建立的治疗算法来治疗患有炎性关节疾病（类风湿性关节炎，牛皮癣性关节炎）的患者通常需要同时使用三种或更多种药物以缓解症状并防止长期关节损伤和残疾。目的就炎症性关节疾病的药物治疗的临床相关性进行评估并进行概述。方法使用三种市售药物相互作用程序评估所有可能的药物组合。在只有有限/没有数据的情况下，对Pubmed进行了全面的手工搜索。最后，根据循证医学和专门生成的基于相关性的系统对所有可能组合的药物相互作用进行分类。结果所有三个交互软件程序均显示出一致的结果。所有检测到的交互都组合在结构清晰的表格中。结论给出了关于药物-药物相互作用的简要概述。特别是在更复杂的情况下，对药物相互作用的广泛了解有助于优化治疗并改善患者安全性。