The spatial organization of the genome contributes to essential functions such as transcription and chromosome integrity maintenance. The principles governing nuclear compartmentalization have been the focus of considerable research over the last decade. In these studies, the genome-nuclear structure interactions emerged as a main driver of this particular 3D genome organization. In this review, we describe the interactions between the genome and four major landmarks of the nucleus: the nuclear lamina, the nuclear pores, the pericentromeric heterochromatin and the nucleolus. We present the recent studies that identify sequences bound to these different locations and address the tethering mechanisms. We give an overview of the relevance of this organization in development and disease. Finally, we discuss the dynamic aspects and self-organizing properties that allow this complex architecture to be inherited.

中文翻译：

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固定在核标志物上的基因组驱动了核空间的功能分区。

基因组的空间组织有助于诸如转录和染色体完整性维持的基本功能。在过去的十年中，控制核隔离的原则一直是大量研究的重点。在这些研究中，基因组与核的结构相互作用是这一特定3D基因组组织的主要驱动力。在这篇综述中，我们描述了基因组与核的四个主要标志之间的相互作用：核层，核孔，着丝粒异染色质和核仁。我们提出了最近的研究，这些研究确定了绑定到这些不同位置的序列并解决了绑定机制。我们概述了该组织在发展和疾病中的相关性。最后，