BACKGROUND Insulin, insulin-like growth factor-1 (IGF-1), and inflammation possibly are involved in cats with asymptomatic hypertrophic cardiomyopathy (aHCM). OBJECTIVES To evaluate echocardiography, morphology, cardiac and inflammatory markers, insulin and IGF-1 in cats with aHCM. ANIMALS Fifty-one client-owned cats with aHCM. METHODS Observational descriptive study. Variables (body weight [BW], body condition score [BCS], echocardiography, and serum concentrations of N-terminal pro-B-type natriuretic peptide [NT-proBNP], ultra-sensitive troponin-I [c-TnI], serum amyloid A [SAA], insulin, glucose and IGF-1) were evaluated for significant increases above echocardiography cutoff values and laboratory reference ranges, associations and effect of left atrial (LA) remodeling and generalized hypertrophy. RESULTS Cats with aHCM had BCS ≥6/9 (P = .01) and insulin (P < .001), NT-proBNP (P = .001) and cTn-I (P < .001) above laboratory reference ranges. Associations were present between NT-proBNP and maximum end-diastolic interventricular septum thickness (IVSd; ρ = .32; P = .05), maximum end-diastolic left ventricular free wall thickness;(ρ = .41; P = .01), LA/Aorta (ρ = .52; P = .001) and LA diameter (LA-max; ρ = .32; P = .05); c-TnI and LA/Aorta (ρ = .49; P = .003) and LA-max (ρ = .28; P = .05); and SAA and number of IVSd regions ≥6 mm thickness (ρ = .28; P = .05). Body weight and BCS were associated with IGF-1 (r = 0.44; P = .001), and insulin (ρ = .33; P = .02), glucose (ρ = .29; P = .04) and IGF-1 (ρ = .32; P = .02), respectively. Concentrations of NT-proBNP (P = .02) and c-TnI (P = .01), and SAA (P = .02), were higher in cats with LA remodeling, and generalized hypertrophy, respectively. CONCLUSIONS AND CLINICAL IMPORTANCE Results suggest potential implications of insulin, IGF-1, and inflammation in cats with aHCM, but it remains to be confirmed whether these findings represent a physiological process or a part of the pathogenesis and development of disease.

中文翻译：

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无症状肥厚型心肌病猫的超声心动图，心脏生物标志物，胰岛素代谢，形态和炎症之间的关联。

背景技术胰岛素，胰岛素样生长因子-1（IGF-1）和炎症可能与无症状肥厚型心肌病（aHCM）的猫有关。目的评估aHCM猫的超声心动图，形态，心脏和炎症标志物，胰岛素和IGF-1。动物有aHCM的51只客户拥有的猫。方法观察性描述性研究。变量（体重[BW]，身体状况评分[BCS]，超声心动图和N端pro-B型利钠肽[NT-proBNP]，超敏肌钙蛋白-I [c-TnI]，血清评估了淀粉样蛋白A [SAA]，胰岛素，葡萄糖和IGF-1在超声心动图截止值和实验室参考范围之上的显着增加，左心房重构和广泛肥大的相关性和影响。结果aHCM猫的BCS≥6/ 9（P =。01）和胰岛素（P <.001），NT-proBNP（P = .001）和cTn-1（P <.001）高于实验室参考范围。NT-proBNP与舒张末期最大心室间隔厚度（IVSd;ρ= .32; P = .05），舒张末期最大左心室游离壁厚度之间存在关联;（ρ= .41; P = .01） ，LA / Aorta（ρ= .52; P = .001）和LA直径（LA-max;ρ= .32; P = .05）；c-TnI和LA / Aorta（ρ= .49; P = .003）和LA-max（ρ= .28; P = .05）; SAA和IVSd区域的数量≥6 mm厚度（ρ= .28； P = .05）。体重和BCS与IGF-1（r = 0.44; P = .001），胰岛素（ρ= .33; P = .02），葡萄糖（ρ= .29; P = .04）和IGF- 1（ρ= .32; P = .02）。在患有LA重塑和全身肥大的猫中，NT-proBNP（P = .02）和c-TnI（P = .01）和SAA（P = .02）的浓度较高，分别。结论和临床意义结果表明，胰岛素，IGF-1和aHCM猫的炎症潜在影响，但这些发现是否代表生理过程或疾病发病机理的发展仍有待确认。