PURPOSE To correlate choriocapillaris (CC) flow deficits (FD) in eyes with geographic atrophy (GA) at various distances from the border of the GA lesion with yearly enlargement rate (yER) of GA. METHODS In this retrospective study, spectral domain optical coherence tomography (SD-OCT) and SD optical coherence tomography angiography (OCTA) images were collected from patients with GA, who were imaged at Doheny Eye Centers between 2016 and 2018, using the Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA). All enrolled patients had one baseline 6 × 6 mm OCTA scan and two 6 × 6 mm SD-OCT cubes, one at baseline and one at a follow-up visit at least 12 months later. The border of the GA was manually outlined on the en face OCT fundus image and the yER was calculated after square root transformation. A grid composed of 100-μm-wide successive concentric rings was created around the GA lesion on the OCTA CC slab using ImageJ and the FD% was calculated from the binarized image. FD% from each ring was correlated with the yER of GA. RESULTS Thirty eyes of 22 patients were included in the study. The mean yER was 0.2 ± 0.15 mm. The FD% in the first five rings (from 0 to 500 μm from the border of GA) was significantly correlated with the yER. However, there was no statistically significant correlation between the yER and CC FD% beyond 500 μm from the GA lesion. CONCLUSIONS Only the choriocapillaris FD% in the 500-μm region immediately surrounding GA lesions appears to predict the rate of enlargement of these lesions.

中文翻译：

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脉络膜毛细血管血流不足的接近性与地理萎缩扩大率之间的关系。

目的将距GA病变边界不同距离的地理萎缩（GA）与脉络膜毛细血管（CC）血流不足（FD）与GA的年增率（yER）相关联。方法在这项回顾性研究中，我们从2016年至2018年之间在Doheny眼中心成像的GA患者收集了使用Cirrus HD-成像的光谱域光学相干断层扫描（SD-OCT）和SD光学相干断层扫描血管造影（OCTA）图像。 10月（Carl Zeiss Meditec，都柏林，CA）。所有入组患者均进行了一次6×6 mm OCTA基线扫描和两个6×6 mm SD-OCT立方体，至少在12个月后进行了一次基线基线和一次随访。在面部OCT眼底图像上手动勾勒出GA的边界，并在平方根变换后计算yER。使用ImageJ在OCTA CC平板上的GA病变周围创建一个由100μm宽的连续同心环组成的网格，并使用二值化图像计算FD％。每个环的FD％与GA的yER相关。结果本研究包括22例患者的30眼。yER的平均值为0.2±0.15毫米。前五个环的FD％（距GA的边界为0至500μm）与yER显着相关。但是，从GA病变开始，超过500μm的yER和CC FD％之间没有统计学显着的相关性。结论仅在GA病变周围500μm区域的脉络膜毛细血管FD％似乎可以预测这些病变的扩大率。每个环的FD％与GA的yER相关。结果本研究包括22例患者的30眼。yER的平均值为0.2±0.15毫米。前五个环的FD％（距GA的边界为0至500μm）与yER显着相关。但是，从GA病变开始，超过500μm的yER和CC FD％之间没有统计学显着的相关性。结论仅在GA病变周围500-μm区域的脉络膜毛细血管FD％似乎可以预测这些病变的扩大率。每个环的FD％与GA的yER相关。结果本研究包括22例患者的30眼。yER的平均值为0.2±0.15毫米。前五个环的FD％（距GA的边界为0至500μm）与yER显着相关。但是，从GA病变开始，超过500μm的yER和CC FD％之间没有统计学显着的相关性。结论仅在GA病变周围500-μm区域的脉络膜毛细血管FD％似乎可以预测这些病变的扩大率。GA病变超过500μm时，yER和CC FD％之间无统计学意义的相关性。结论仅在GA病变周围500-μm区域的脉络膜毛细血管FD％似乎可以预测这些病变的扩大率。距GA病变超过500μm时，yER和CC FD％之间无统计学意义的相关性。结论仅在GA病变周围500-μm区域的脉络膜毛细血管FD％似乎可以预测这些病变的扩大率。