BACKGROUND In adolescents with chronic kidney disease (CKD), menstrual disorders (MD) are common, which can make the management of CKD difficult and can sometimes delay renal transplantation. This study aimed to identify the usefulness of hormonal measurements in adolescents with CKD and their relationships with MD during a 1-year follow-up. METHODS A prospective cohort study was designed. Adolescents with CKD stages IV and V were included. Through clinical files and via interview, the ages at puberty onset, menarche and the date of last menstruation were identified. A 1-year follow-up was conducted over a menstrual cycle calendar. At the beginning of follow-up, routine hormonal profiles (thyroid profiles, prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and estradiol) were assessed. We compared the hormonal profiles of the patients with and without MD (wMD vs. woMD). Comparisons between groups were made by Wilcoxon and Fisher's tests. Logistic regression analysis was used. RESULTS Fifty-seven patients, including 30 patients classified as wMD, were analyzed. The median age was 15 years, and the median time of CKD evolution was 18 months. There were no differences in general and biochemical characteristics between patients wMD and woMD. In terms of hormonal measurements, the levels of thyroid-stimulating hormone (TSH) and prolactin were higher in the wMD patients. A prolactin level ≥ 36.8 ng/ml was a risk factor for presenting with MD (RR 34.4, p = 0.002). CONCLUSIONS Hyperprolactinemia is correlated with MD in adolescents with CKD.

中文翻译：

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高泌乳素血症是晚期慢性肾脏病女性青少年月经失调的预后因素。

背景技术在患有慢性肾脏病（CKD）的青少年中，月经失调（MD）很常见，这可能会使CKD的治疗变得困难，并且有时会延迟肾脏移植。这项研究旨在确定在1年的随访中，对患有CKD的青少年进行激素测量的有用性及其与MD的关系。方法设计了一项前瞻性队列研究。包括CKD IV和V期的青少年。通过临床档案和访谈，可以确定青春期的发病年龄，初潮和最后一次月经的日期。在月经周期中进行了为期1年的随访。在随访开始时，评估了常规荷尔蒙特征（甲状腺特征，催乳素，促黄体激素（LH），促卵泡激素（FSH）和雌二醇）。我们比较了有和没有MD的患者的激素状况（wMD与woMD）。两组之间的比较是通过Wilcoxon和Fisher的检验进行的。使用逻辑回归分析。结果分析了57例患者，其中30例被分类为wMD。中位年龄为15岁，CKD进化的中位时间为18个月。wMD和woMD患者的一般和生化特征无差异。在激素测量方面，wMD患者的甲状腺刺激激素（TSH）和催乳激素水平较高。催乳素水平≥36.8 ng / ml是出现MD的危险因素（RR 34.4，p = 0.002）。结论高泌乳素血症与CKD青少年的MD有关。两组之间的比较是通过Wilcoxon和Fisher的检验进行的。使用逻辑回归分析。结果分析了57例患者，其中30例被分类为wMD。中位年龄为15岁，CKD进化的中位时间为18个月。wMD和woMD患者的一般和生化特征无差异。在激素测量方面，wMD患者的甲状腺刺激激素（TSH）和催乳激素水平较高。催乳素水平≥36.8 ng / ml是出现MD的危险因素（RR 34.4，p = 0.002）。结论高泌乳素血症与CKD青少年的MD有关。两组之间的比较是通过Wilcoxon和Fisher的检验进行的。使用逻辑回归分析。结果分析了57例患者，其中30例被分类为wMD。中位年龄为15岁，CKD进化的中位时间为18个月。wMD和woMD患者的一般和生化特征无差异。在激素测量方面，wMD患者的甲状腺刺激激素（TSH）和催乳激素水平较高。催乳素水平≥36.8 ng / ml是出现MD的危险因素（RR 34.4，p = 0.002）。结论高泌乳素血症与CKD青少年的MD有关。中位年龄为15岁，CKD进化的中位时间为18个月。wMD和woMD患者的一般和生化特征无差异。在激素测量方面，wMD患者的甲状腺刺激激素（TSH）和催乳激素水平较高。催乳素水平≥36.8 ng / ml是出现MD的危险因素（RR 34.4，p = 0.002）。结论高泌乳素血症与CKD青少年的MD有关。中位年龄为15岁，CKD进化的中位时间为18个月。wMD和woMD患者的一般和生化特征无差异。在激素测量方面，wMD患者的甲状腺刺激激素（TSH）和催乳激素水平较高。催乳素水平≥36.8 ng / ml是出现MD的危险因素（RR 34.4，p = 0.002）。结论高泌乳素血症与CKD青少年的MD有关。002）。结论高泌乳素血症与CKD青少年的MD有关。002）。结论高泌乳素血症与CKD青少年的MD有关。