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Characteristics and the role of purinergic receptors in pathophysiology with focus on immune response.
International Reviews of Immunology ( IF 5 ) Pub Date : 2020-02-09 , DOI: 10.1080/08830185.2020.1723582
Marharyta Zyma 1 , Rafał Pawliczak 1
Affiliation  

The nucleotide adenosine-5'-triphosphate (ATP) is mostly thought to be energy carrier, but evidence presented in multiple studies proves ATP involvement into variety of processes, due to its neuromodulatory capabilities. ATP and its metabolite-adenosine, bind to the purinergic receptors, which are divided into two types: adenosine binding P1 receptor and ADP/ATP binding P2 receptor. These receptors are expressed in different tissues and organs. Recent studies report their immunomodulatory characteristics, connected with varying immunological processes, such as immunological response or antigen presentation. Besides, they seem to play an important role in medical conditions such as bronchial asthma or variety of cancers. In this article, we would like to review recent discoveries on the field of purinergic receptors research focusing on their role in immunological system, and shed a new light upon the importance of these receptors in modern medicine development.

中文翻译:

嘌呤能受体的特征及其在病理生理中的作用,重点是免疫反应。

核苷酸5'-三磷酸腺苷(ATP)通常被认为是能量载体,但是多项研究提供的证据证明,ATP具有神经调节功能,可参与多种过程。ATP及其代谢物腺苷与嘌呤能受体结合,嘌呤能受体分为两种类型:腺苷结合P1受体和ADP / ATP结合P2受体。这些受体在不同的组织和器官中表达。最近的研究报告了它们的免疫调节特性,与各种免疫过程有关,例如免疫应答或抗原呈递。此外,它们在支气管哮喘或各种癌症等医学疾病中似乎起着重要作用。在这篇文章中,
更新日期:2020-04-21
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