Acute myocardial infarction (AMI) remains the most severe and common cardiac emergency among various ischaemic heart diseases. Both unregulated (necrosis) and regulated (apoptosis, autophagy and necroptosis et al.) forms of cell death can occur during AMI. Non-invasive imaging of cardiomyocyte death represents an attractive approach to acquire insights into the pathophysiology of AMI, track the temporal and spatial evolution of MI, guide therapeutic decision-making, evaluate response to therapeutic intervention and predict prognosis. Although several forms of cell death have been identified during AMI, to date, only apoptosis- and necrosis-detecting probes compatible with currently available tomographic imaging modalities have been successfully developed for non-invasive visualisation of cardiomyocyte death. Myocardial apoptosis imaging has gained more attention because of its potential controllability while less attention has been paid to myocardial necrosis imaging. In our opinion, although cardiomyocyte necrosis is unsalvageable, imaging necrosis can play an important role in early diagnosis, risk stratification, prognostic prediction and guidance in therapeutic decision-making of AMI. In this mini-review, we summarise the updated advances achieved by us and others and discuss the challenges in the development of molecular imaging probes for visualisation of myocardial necrosis.

急性心肌梗死 (AMI) 仍然是各种缺血性心脏病中最严重和最常见的心脏急症。AMI 期间可能发生不受调节（坏死）和受调节（细胞凋亡、自噬和坏死性凋亡等）形式的细胞死亡。心肌细胞死亡的非侵入性成像代表了一种有吸引力的方法，可以深入了解 AMI 的病理生理学、跟踪 MI 的时空演变、指导治疗决策、评估对治疗干预的反应和预测预后。虽然在 AMI 期间已经确定了几种形式的细胞死亡，但迄今为止，只有与当前可用的断层扫描成像模式兼容的细胞凋亡和坏死检测探针已成功开发用于非侵入性的心肌细胞死亡可视化。心肌细胞凋亡成像因其潜在的可控性而受到更多关注，而心肌坏死成像却很少受到关注。我们认为，尽管心肌细胞坏死是不可挽救的，但影像学坏死在 AMI 的早期诊断、风险分层、预后预测和指导治疗决策中可以发挥重要作用。在这篇小型综述中，我们总结了我们和其他人取得的最新进展，并讨论了开发用于心肌坏死可视化的分子成像探针的挑战。AMI 治疗决策的预后预测和指导。在这篇小型综述中，我们总结了我们和其他人取得的最新进展，并讨论了开发用于心肌坏死可视化的分子成像探针的挑战。AMI 治疗决策的预后预测和指导。在这篇小型综述中，我们总结了我们和其他人取得的最新进展，并讨论了开发用于心肌坏死可视化的分子成像探针的挑战。